Results 71 to 80 of about 8,830,354 (289)
Le attività di NAIS e la piattaforma Web sviluppata per il progetto ArTeK
Archeomatica, 2018 NAIS Nextant Applications and Innovative Services
doaj +3 more sources
Being pragmatic about healthcare complexity: our experiences applying complexity theory and pragmatism to health services research [PDF]
, 2018 Katrina M. Long +2 more
openalex +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Factors Influencing Digital Transformation of Logistics Service Providers: A Case Study in Thailand [PDF]
, 2021 Putthiwat Singhdong +2 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Foreign Trade of the Republic of Belarus in the International Business Environment
Bulletin of Geography. Socio-Economic Series, 2019 The aim of the paper is to assess the current state, problems and prospects for the development of foreign trade in the Republic of Belarus in the international business environment. The evaluation of foreign trade indicators is based on information from
Hrechyshkina Olena, Samakhavets Maryia
doaj +1 more source
Electric Vehicles Selection Based on Brčko District Taxi Service Demands, a Multi-Criteria Approach [PDF]
, 2022 Anđelka Štilić +3 more
openalex +1 more source