Parthenin-A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects. [PDF]
Molecules, 2021 Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed Parthenium hysterophorus (Asteraceae).
Kaur A +7 more
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Acta Pharmaceutica, 2020 Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone ...
Onoja Samuel O. +3 more
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Successful treatment of airborne allergic dermatitis to sesquiterpene lactone with upadacitinib: A case report [PDF]
SAGE Open Medical Case ReportsThis case report describes, to our knowledge, the first known successful treatment of airborne allergic contact dermatitis to sesquiterpene lactone with upadacitinib in an adult patient.
Barbara Marzario +2 more
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Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential. [PDF]
Int J Mol Sci, 2019 Sesquiterpene lactones constitute a major class of bioactive natural products. One of the naturally occurring sesquiterpene lactones is costunolide, which has been extensively investigated for a wide range of biological activities.
Kim DY, Choi BY.
europepmc +2 more sources
Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo. [PDF]
Viruses, 2019 With the emergence of drug-resistant strains of influenza A viruses (IAV), new antivirals are needed to supplement the existing counter measures against IAV infection.
Zhang X +5 more
europepmc +2 more sources
Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-κB Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer. [PDF]
Sci Rep, 2019 The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET) are known to exhibit activities against some cancer types. The activities of these lactones against breast cancer and the molecular bases is not known.
Verma SS +6 more
europepmc +2 more sources
A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic acid) Isolated from Burdock Leaf Up-Regulates Cells’ Oxidative Stress Defense Pathway [PDF]
Antioxidants, 2021 The aim of our study was to identify novel molecules able to induce an adaptative response against oxidative stress during the first stages of metabolic syndrome.
Yanis A. Idres +6 more
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BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide [PDF]
Beilstein Journal of Organic Chemistry, 2017 Like thapsigargin, which is undergoing clinical trials, trilobolide is a natural product with promising anticancer and anti-inflammatory properties. Similar to thapsigargin, it has limited aqueous solubility that strongly reduces its potential medicinal ...
Ludmila Škorpilová +10 more
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The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress. [PDF]
Biomedicines, 2022 Rotondo R, Oliva MA, Arcella A.
europepmc +3 more sources
Covalent Modification of Human Serum Albumin by the Natural Sesquiterpene Lactone Parthenolide
Molecules, 2015 The reactivity of parthenolide (PRT), a natural sesquiterpene lactone from Tanacetum parthenium (Asteraceae), with human serum albumin (HSA) was studied by UHPLC/+ESI-QqTOF MS analysis after tryptic digestion of albumin samples after incubation with this
Michael Plöger +3 more
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