Results 21 to 30 of about 9,505 (220)

Natural sesquiterpen lactones as acetylcholinesterase inhibitors [PDF]

Anais da Academia Brasileira de Ciências, 2014
Background and the purpose of the study: The amount of elder people who suffer from Alzheimer disease is continuously increasing every year. Cholinesterase inhibitors have shown to be effective in alleviating the symptoms of the disease, thus opening a field of research for these treatments.
HAJIMEHDIPOOR, HOMA, MOSADDEGH, MAHMOUD, NAGHIBI, FARZANEH, HAERI, ALI, HAMZELOO-MOGHADAM, MARYAM   +4 more
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Root constituents of Lactuca sibirica and a comparison of metabolite profiles of L. sibirica and L. tatarica

Acta Societatis Botanicorum Poloniae, 2011
Nine known sesquiterpene lactones, including four lactucin-type guaianolides, four costuslactone-type guaianolides and one germacranolide, were isolated from roots of Lactuca sibirica (Asteraceae), six of which were glycoside derivatives.
Wanda Kisiel, Klaudia Michalska
doaj   +1 more source

Targeted Screening and Quantification of Characteristic Sesquiterpene Lactones in Ambrosia artemisiifolia L. at Different Growth Stages

Plants
Sesquiterpene lactones are specialized plant metabolites with promising pharmacological activities. These metabolites are characteristic marker compounds for the aerial parts of Ambrosia artemisiifolia.
Balázs Kovács, Péter Püski, Ákos Bajtel, Elek Ferencz, Boglárka Csupor-Löffler, Dezső Csupor, Tivadar Kiss   +6 more
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Sesquiterpene Lactones Containing an α-Methylene-γ-Lactone Moiety Selectively Down-Regulate the Expression of Tumor Necrosis Factor Receptor 1 by Promoting Its Ectodomain Shedding in Human Lung Adenocarcinoma A549 Cells

Molecules
Alantolactone is a eudesmane-type sesquiterpene lactone containing an α-methylene-γ-lactone moiety. Previous studies showed that alantolactone inhibits the nuclear factor κB (NF-κB) signaling pathway by targeting the inhibitor of NF-κB (IκB) kinase ...
Quy Van Vu, Shinsei Sayama, Masayoshi Ando, Takao Kataoka   +3 more
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9-Hydroxyfurodysinin-O-ethyl Lactone: A New Sesquiterpene Isolated from the Tropical Marine Sponge Dysidea arenaria

Molecules, 2005
A new sesquiterpene, 9-hydroxyfurodysinin-O-ethyl lactone, has been isolated from a New Caledonian Dysidea arenaria, along with three known compounds. The possible incorporation of the ethyl ether from the extraction solvent is discussed.
P. Karuso, A. Piggott
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Natural Product Alantolactone Targeting AKR1C1 Suppresses Cell Proliferation and Metastasis in Non-Small-Cell Lung Cancer

Frontiers in Pharmacology, 2022
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, characterized by high invasion and metastasis. Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis ...
Zhiwen Fu, Zhiwen Fu, Shijun Li, Shijun Li, Jinmei Liu, Jinmei Liu, Cong Zhang, Cong Zhang, Chen Jian, Chen Jian, Lulu Wang, Lulu Wang, Yu Zhang, Yu Zhang, Chen Shi, Chen Shi   +15 more
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Plant sesquiterpene lactones

Philosophical Transactions of the Royal Society B: Biological Sciences
Sesquiterpene lactones (STLs) are a prominent group of plant secondary metabolites predominantly found in the Asteraceae family and have multiple ecological roles and medicinal applications. This review describes the evolutionary and ecological significance of STLs, highlighting their roles in plant defence mechanisms against herbivory and as ...
Olivia Agatha, Daniela Mutwil-Anderwald, Jhing Yein Tan, Marek Mutwil   +3 more
openaire   +3 more sources

Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Nature Communications, 2016
Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets.
Roman Lagoutte, Christelle Serba, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian, Nicolas Winssinger   +5 more
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Aromaticine, a sesquiterpene lactone from Amblyopappus pusillus

Acta Crystallographica Section E, 2008
Aromaticine (systematic name: 4a,8-dimethyl-3-methylene-3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione), C15H18O3, is a natural lactone isolated from Amblyopappus pusillus.
Matías López-Rodríguez, Luis Alberto Loyola, Jorge Bórquez, Iván Brito   +3 more
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(1R,4R,5aS,7S,9aS)-7,9a-Dimethyl-6-methylene-3-oxo-1,3,4,5,5a,6,7,8,9,9a-decahydronaphtho[1,2-c]furan-1,4-diyl diacetate

Acta Crystallographica Section E, 2012
The title compound, C19H24O6, is a sesquiterpene lactone isolated from the Kenyan plant Warburgia ugandensis. Ring A adopts a chair conformation, ring B is in a C2 twist conformation and the lactone ring is nearly planar with maximum deviation 0.007&#
Mercy Mudyiwa, Mohamed S. Rajab, Frank R. Fronczek, Steven F. Watkins   +3 more
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