Results 51 to 60 of about 97,347 (301)

Adenoid cystic carcinoma: emerging role of translocations and gene fusions. [PDF]

, 2016
Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease.
Brait, Mariana, Ha, Patrick K, Izumchenko, Evgeny, Meir, Juliet, Sidransky, David, Wysocki, Piotr T   +5 more
core   +3 more sources

Sesquiterpene Lactones Containing an α-Methylene-γ-Lactone Moiety Selectively Down-Regulate the Expression of Tumor Necrosis Factor Receptor 1 by Promoting Its Ectodomain Shedding in Human Lung Adenocarcinoma A549 Cells

Molecules
Alantolactone is a eudesmane-type sesquiterpene lactone containing an α-methylene-γ-lactone moiety. Previous studies showed that alantolactone inhibits the nuclear factor κB (NF-κB) signaling pathway by targeting the inhibitor of NF-κB (IκB) kinase ...
Quy Van Vu, Shinsei Sayama, Masayoshi Ando, Takao Kataoka   +3 more
doaj   +1 more source

9-Hydroxyfurodysinin-O-ethyl Lactone: A New Sesquiterpene Isolated from the Tropical Marine Sponge Dysidea arenaria

Molecules, 2005
A new sesquiterpene, 9-hydroxyfurodysinin-O-ethyl lactone, has been isolated from a New Caledonian Dysidea arenaria, along with three known compounds. The possible incorporation of the ethyl ether from the extraction solvent is discussed.
P. Karuso, A. Piggott
doaj   +1 more source

Vlasoulamine A, a Neuroprotective [3.2.2]Cyclazine Sesquiterpene Lactone Dimer from the Roots of Vladimiria souliei.

Organic Letters, 2018
Vlasoulamine A (1), an unprecedented sesquiterpene lactone dimer featuring a fully hydrogenated pyrrolo[2,1,5- cd]indolizine core, and vlasoulones A and B (2 and 3), a pair of epimeric dimers formed from a proposed Diels-Alder [4 + 2] cycloaddition ...
Zhi-Li Wu, Qun Wang, Jinxin Wang, Hong-yuan Dong, Xi-ke Xu, Yun-Heng Shen, Huiliang Li, Wei-Dong Zhang   +7 more
semanticscholar   +1 more source

EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells [PDF]

, 2016
Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants and found to have potential anticancer activities. However, the intracellular molecular targets of SLs and the underlying molecular mechanisms have not been well ...
Chen, WB, Li, HY, Li, MM, Li, YL, Liu, QY, Liu, Z, Ma, DL, Shao, FY, Wang, GC, Wang, S, Wang, YF, Wong, NS, Xiao, H, Zhou, GX   +13 more
core   +1 more source

Method development and validation for the extraction and quantification of sesquiterpene lactones in Dolomiaea costus

Ultrasonics Sonochemistry
Dolomiaea costus, commonly known as Indian costus, is a medicinal plant from the Asteraceae family. The root and powder of costus have been widely used to treat various health conditions.
Mohammed Aldholmi
doaj   +1 more source

Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Nature Communications, 2016
Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets.
Roman Lagoutte, Christelle Serba, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian, Nicolas Winssinger   +5 more
doaj   +1 more source

Natural Product Alantolactone Targeting AKR1C1 Suppresses Cell Proliferation and Metastasis in Non-Small-Cell Lung Cancer

Frontiers in Pharmacology, 2022
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, characterized by high invasion and metastasis. Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis ...
Zhiwen Fu, Zhiwen Fu, Shijun Li, Shijun Li, Jinmei Liu, Jinmei Liu, Cong Zhang, Cong Zhang, Chen Jian, Chen Jian, Lulu Wang, Lulu Wang, Yu Zhang, Yu Zhang, Chen Shi, Chen Shi   +15 more
doaj   +1 more source

Identification and characterization of five anti-mitotic sesquiterpene lactones from <i>Arnica cordifolia</i>. [PDF]

Pharm Biol
Lockwood TC, Williams DE, Molina L, Andersen RJ, Golsteyn RM.   +4 more
europepmc   +2 more sources

Uma proposta para o controle de qualidade de Tanacetum parthenium (tanaceto) e seu extrato hidroalcoólico [PDF]

, 2008
In this study, we present a proposal for the physical and chemical quality control of the powder of the species T. parthenium (feverfew) and its hydroalcoholic extract obtained by percolation.
CHAVES, Juliana Siqueira, DA COSTA, Fernando Batista   +1 more
core   +1 more source