Results 61 to 70 of about 9,505 (220)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, Volume 12, Issue 27, July 17, 2025.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Sesquiterpene lactones from Chrysolaena platensis

Biochemical Systematics and Ecology, 2000
Fil: Pollora, Genaro Cesar. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Tucuman. Instituto de Quimica del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia.
Pollora, Genaro Cesar, Bardon, Alicia del Valle, Catalan, Cesar Atilio Nazareno, Gedris, Thomas E., Herz, Werner   +4 more
openaire   +4 more sources

Lettuce Anaphylaxis in a Florist With Hand Dermatitis and Contact Allergy to the Compositae (Asteraceae) Family of Plants

Contact Dermatitis, EarlyView.
Lara Obermeyer, Monika Raulf, Irene Mittermann, Martina Aumayr, Christoph Skudlik, Richard Brans   +5 more
wiley   +1 more source

Apteranthes tuberculata's Antidiabetic Potential: Exploring Phytochemicals, Screening Antioxidant Activity, and Validating DPP‐4 Inhibition Using In Vitro and In Silico Approaches

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Metabolomics revealed 24 major compounds, mainly glycosides, flavonoids, and triterpenes. Antidiabetic compounds Kaempferol‐7‐O‐rutinoside and Kaempferol‐3‐O‐rutinoside‐7‐O‐glucoside show maximum inhibiting activity for DPP4 protein (in vitro and in silico). Out of 24 compounds, 5 demonstrate no PAINS and break alerts.
Ilham Khan, Shabana Bibi, Junaid Shehzad, Zarqa Riaz, Muhammad Saad Khan, Mansour Ghorbanpour, Murtaza Hasan, Ghazala Mustafa   +7 more
wiley   +1 more source

Isolation of a natural product with anti-mitotic activity from a toxic Canadian prairie plant

Heliyon, 2021
We are investigating plants from the prairie ecological zone of Canada to identify natural products that inhibit mitosis in cancer cells. Investigation of plant parts from the Canadian plant species Hymenoxys richardsonii (Asteraceae) revealed that leaf ...
Layla Molina, David E. Williams, Raymond J. Andersen, Roy M. Golsteyn   +3 more
doaj  

Prospects for the use of natural terpenoids in agriculture [PDF]

BIO Web of Conferences
As a result of the conducted phytochemical studies of sesquiterpene lactones of some plants of the genus Artemisia, Centaurea, Jurinea, and Handelia of the Asteraceae family and the study of biostimulating, mutagenic, and insecticidal activity of ...
Mukhidova Zulfiya Sh., Zakirov Salakhutdin H., Khazratkulova Sevara M., Zakirova Nodira T.   +3 more
doaj   +1 more source

Centaurea lycaonica Extracts Induce Apoptosis in HeLa Human Cervical Cancer Cells via Bax/Bcl‐2 Modulation and Caspase Activation: An LC‐HRMS‐Based Study

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This study highlights the pharmacological mechanisms of dichloromethane (CHD) and methanol (CHM) extracts of Centaurea lycaonica Boiss. & Heldr. herba as the induction of apoptosis on HeLa cells. Apoptotic properties of CHD and CHM are through suppression of Bcl‐2 and increase in Bax, caspase 9, and 3 activities on HeLa cells.
Ayşe Kübra Karaboğa Arslan, Safa Eminoğlu, Leyla Paşayeva, Nuh Mehmet Bozkurt, Osman Tugay   +4 more
wiley   +1 more source

Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.

PLoS ONE, 2013
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemotherapeutic resistance and increased metastatic potential.
Birgit Lohberger, Beate Rinner, Nicole Stuendl, Heike Kaltenegger, Bibiane Steinecker-Frohnwieser, Eva Bernhart, Ehsan Bonyadi Rad, Annelie Martina Weinberg, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer   +10 more
doaj   +1 more source

Sesquiterpene lactones from Tanacetum ferulaceum

Phytochemistry, 1990
2341
González, Antonio G., Bermejo, Jaime, Triana, Jorge, López Sánchez, Mariana, Eiroa, José L.   +4 more
openaire   +4 more sources

Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction

European Journal of Medicinal Chemistry Reports, 2022
The GDP/GTP conformational change of Arf GTPase proteins by different guanine exchange factor GEFs proteins (Big1Sec7, ARNOSec7, Brag1Sec7, etc.), modulates important eukaryotes cell functions, such as secretion, endocytosis, phagocytosis, cytokinesis ...
Sergio Ortiz, François Peurois, Euzébio Guimarães Barbosa, Mohamed Selkti, Pascale Lemoine, Jacqueline Cherfils, Raphaël Grougnet, Sabrina Boutefnouchet   +7 more
doaj