Results 321 to 330 of about 83,124 (381)

Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis.

Journal of the American Chemical Society, 2023
The cyclization of farnesyl diphosphate (FPP) into highly strained polycyclic sesquiterpenes is challenging. We here determined the crystal structures of three sesquiterpene synthases (STSs, namely, BcBOT2, DbPROS, and CLM1) catalyzing the biosynthesis ...
Tingting Lou, Annan Li, Houchao Xu, Jingfeng Pan, B. Xing, Ruibo Wu, Jeroen S. Dickschat, Donghui Yang, M. Ma   +8 more
semanticscholar   +1 more source

Three Unusual Sesquiterpenes with Distinctive Ring Skeletons from Daphne penicillata Uncovered by Molecular Networking Strategies.

Journal of Organic Chemistry, 2021
Daphnenoids A-C (1-3), three unusual sesquiterpenes with distinctive ring skeletons, together with a biogenetically related daphnenoid D (4) were obtained from the herb of Daphne penicillata by molecular networking strategies.
Peng Zhao, Zhi-Yuan Li, Shu-Yan Qin, Ben-Song Xin, Yu-Yang Liu, B. Lin, Guo-Dong Yao, Xiao-Xiao Huang, Shaojiang Song   +8 more
semanticscholar   +1 more source

Sesquiterpenes and Steroids from an Endophytic Eutypella scoparia.

Journal of Natural Products, 2021
A chemical investigation on the EtOAc extract of the endophytic fungus Eutypella scoparia SCBG-8 led to the isolation of eight new sesquiterpenes eutyscoparins A-H (1-8), one C-28 steroid eutyscoparene A (9), one triterpenoid eutyscoparene B (10), six ...
Wenge Zhang, Xiuxiang Lu, Luqiong Huo, Sha Zhang, Yan Chen, Zhen-xing Zou, Haibo Tan   +6 more
semanticscholar   +1 more source

Hepatotoxicity of monoterpenes and sesquiterpenes

Archives of Toxicology, 2017
Public interest in natural therapies has increased significantly over past decades. Herbs and herbal products are extensively consumed worldwide and they are generally considered as safe. However, this may not always be true as many cases of herb-induced liver injury are reported every year.
T. Zárybnický, I. Boušová, M. Ambroz, L. Skálová   +3 more
semanticscholar   +4 more sources

Sesquiterpenes as Immunosuppressants

Transplantation, 2009
The search for new immunosuppressive drugs is a high priority. Sesquiterpenes constitute a family of compounds with a great variety of biological activities due to their reactive moieties.Human tumor cell lines and murine primary cells and human peripheral blood mononuclear cells or primary CD4+ cells from healthy individuals were stimulated in the ...
David Chinchilla, Susana Aguilar, Manuel Rodríguez-Iglesias, José M. G. Molinillo, Francisco García-Cózar, Alba Muñoz-Suano, Francisco A. Macías   +6 more
openaire   +3 more sources

Sesquiterpene Lactones as Allelochemicals

Journal of Natural Products, 2006
Six new sesquiterpene lactones, annuolide H (3), helivypolides F, H-J (4, 11-13), and helieudesmanolide A (6), together with known compounds, were isolated from polar bioactive fractions of Helianthus annuus cv. SH-222 and Stella fresh leaf water extracts.
Macias, Francisco A., Fernandez, Adriana, Varela, Rosa M., Molinillo, Jose M. G., Torres, Ascension, Alves, Pedro L. C. A.   +5 more
openaire   +4 more sources

A further sesquiterpene lactone esterified with a sesquiterpenic acid

Phytochemistry, 1982
Abstract The roots of Hypochoeris oligocephala afforded in addition to known compounds a further sesquiterpene lactone esterified with a sesquiterpenic acid as well as the corresponding free acid.
Rajinder K. Gupta, Jasmin Jakupovic, Ferdinand Bohlmann   +2 more
openaire   +2 more sources

Recent Nano-based therapeutic intervention of Bioactive Sesquiterpenes: Prospects in cancer therapeutics.

Current pharmaceutical design, 2020
In recent scenario, nanotechnology based therapeutics intervention has gained tremendous impetus all across the globe. Nano-based pharmacological intervention of various bioactive compounds has been explored on an increasing scale.
M. Ansari, Khan Farheen Badrealam, Asrar Alam, Saba Tufail, Gulshan Khalique, M. J. Equbal, M. Alzohairy, A. Almatroudi, M. Alomary, F. Pottoo   +9 more
semanticscholar   +1 more source

The first sesquiterpene lactones esterified with a sesquiterpenic acid

Phytochemistry, 1981
Abstract From Hypochoeris glabra two guaianolides esterified with an unusual sesquiterpenic acid were isolated. Proton-catalysed rearrangement of the cyclopropane derivative led to a phenolic acid. The structures were elucidated by high-field 1 H NMR spectroscopy. Further guaianolides were isolated from H. uniflora and Lactuca floridana . These
Wolf-Rainer Abraham, Christa Zdero, Jasmin Jakupovic, Ferdinand Bohlmann   +3 more
openaire   +2 more sources

Sesquiterpene coumarins

Phytochemistry Reviews, 2011
Plants have a long history as therapeutic tools in the treatment of human diseases and have been used as a source of medicines for ages. In search of new biologically active natural products, many plants and herbs used in traditional medicine are screened for natural products with pharmacological activity.
Peter E. Brodelius, Anna Gliszczyńska
openaire   +2 more sources