Results 61 to 70 of about 105,849 (264)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Best Proximity Pairs for Upper Semicontinuous Set-Valued Maps in Hyperconvex Metric Spaces
Fixed Point Theory and Applications, 2008 A best proximity pair for a set-valued map with respect to a map is defined, and new existence theorems of best proximity pairs for upper semicontinuous set-valued maps with respect to a homeomorphism are proved in hyperconvex metric spaces.
Farajzadeh AP +3 more
doaj
On a Friction Oscillator of Integer and Fractional Order; Stick–Slip Attractors
Fractal and FractionalThis paper investigates a friction oscillator model in both its Integer-Order and Fractional-Order formulations. The lack of classical solutions for the governing differential equations with discontinuous right-hand sides is addressed by adopting a ...
Marius-F. Danca
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mathematics, 2017 In the present article, we introduce the new concept of start point in a directed graph and provide the characterizations required for a directed graph to have a start point.
Murchana Neog, Pradip Debnath
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A stochastic model for retinocollicular map development
BMC Neuroscience, 2004 Background We examine results of gain-of-function experiments on retinocollicular maps in knock-in mice [Brown et al. (2000) Cell 102:77]. In wild-type mice the temporal-nasal axis of retina is mapped to the rostral-caudal axis of superior colliculus ...
Tsigankov Dmitry N, Koulakov Alexei A
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On a fractional integro-differential inclusion
Electronic Journal of Qualitative Theory of Differential Equations, 2014 We study a Cauchy problem for a fractional integro-differential inclusion of order $\alpha \in (1,2]$ involving a nonconvex set-valued map. Arcwise connectedness of the solution set is provided.
Aurelian Cernea
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source