Results 91 to 100 of about 326,383 (284)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The pointwise limit of metric integral operators approximating set-valued functions
, 2023 For set-valued functions (SVFs, multifunctions), mapping a compact interval $[a,b]$ into the space of compact non-empty subsets of ${\mathbb R}^d$, we study approximation based on the metric approach that includes metric linear combinations, metric selections and weighted metric integrals.
Berdysheva, Elena E. +3 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
IEEE Access, 2019 In multi-criteria decision making (MCDM), it is difficult for decision-makers to give accurate evaluation values, and one-dimensional fuzzy set theory cannot capture periodic and seasonal information.
Jian-Ping Fan, Rui Cheng, Mei-Qin Wu
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
IEEE Access, 2019 Considering decision makers (DMs) maybe hesitant among a set of values when determining the membership and non-membership degrees in a q-rung orthopair fuzzy environment, the q-rung dual hesitant fuzzy sets (q-RDHFS) were proposed.
Yuan Xu +5 more
doaj +1 more source
On Lower Semicontinuity and Metric Upper Semicontinuity of Nemytskii Set-Valued Operators
Zeitschrift für Analysis und ihre Anwendungen, 1994 Sufficient conditions of lower semicontinuity and metric upper semicontinuity of Nemytskii set-valued operators N_F generated by a set-valued function F: \Omega \times X \to 2^Y
Rolewicz, S., Wen, Song
openaire +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source