Results 81 to 90 of about 5,601,704 (278)

Partial Smoothness, Subdifferentials and Set-valued Operators

Over the past decades, the concept "partial smoothness" has been playing as a powerful tool in several fields involving nonsmooth analysis, such as nonsmooth optimization, inverse problems and operation research, etc. The essence of partial smoothness is that it builds an elegant connection between the optimization variable and the objective function ...
Qin, Ziqi, Liang, Jingwei
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

On Lower Semicontinuity and Metric Upper Semicontinuity of Nemytskii Set-Valued Operators

Zeitschrift für Analysis und ihre Anwendungen, 1994
Sufficient conditions of lower semicontinuity and metric upper semicontinuity of Nemytskii set-valued operators N_F generated by a set-valued function F: \Omega \times X \to 2^Y
Rolewicz, S., Wen, Song
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Probabilistic Interval-Valued Hesitant Fuzzy Information Aggregation Operators and Their Application to Multi-Attribute Decision Making

Algorithms, 2018
Based on the probabilistic interval-valued hesitant fuzzy information aggregation operators, this paper investigates a novel multi-attribute group decision making (MAGDM) model to address the serious loss of information in a hesitant fuzzy information ...
Wenying Wu, Ying Li, Zhiwei Ni, Feifei Jin, Xuhui Zhu   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Metric Approximation of Set-Valued Functions of Bounded Variation by Integral Operators

Constructive Approximation
Abstract We introduce an adaptation of integral approximation operators to set-valued functions (SVFs, multifunctions), mapping a compact interval [a, b] into the space of compact non-empty subsets of $${\mathbb {R}}^d$$ R
Elena E. Berdysheva, Nira Dyn, Elza M. Farkhi, Alona Mokhov   +3 more
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Extended EDAS Methods for Multi-Criteria Group Decision-Making Based on IV-CFSWAA and IV-CFSWGA Operators With Interval-Valued Complex Fuzzy Soft Information

IEEE Access, 2019
In multi-criteria decision making (MCDM), it is difficult for decision-makers to give accurate evaluation values, and one-dimensional fuzzy set theory cannot capture periodic and seasonal information.
Jian-Ping Fan, Rui Cheng, Mei-Qin Wu
doaj   +1 more source