Results 71 to 80 of about 8,676 (264)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Metric Approximation of Set-Valued Functions of Bounded Variation by Integral Operators
Constructive ApproximationAbstract We introduce an adaptation of integral approximation operators to set-valued functions (SVFs, multifunctions), mapping a compact interval [a, b] into the space of compact non-empty subsets of $${\mathbb {R}}^d$$ R
Elena E. Berdysheva +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
IEEE Access, 2019 In multi-criteria decision making (MCDM), it is difficult for decision-makers to give accurate evaluation values, and one-dimensional fuzzy set theory cannot capture periodic and seasonal information.
Jian-Ping Fan, Rui Cheng, Mei-Qin Wu
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Partial Smoothness, Subdifferentials and Set-valued Operators
Over the past decades, the concept "partial smoothness" has been playing as a powerful tool in several fields involving nonsmooth analysis, such as nonsmooth optimization, inverse problems and operation research, etc. The essence of partial smoothness is that it builds an elegant connection between the optimization variable and the objective function ...
Qin, Ziqi, Liang, Jingwei
openaire +2 more sources
IEEE Access, 2019 Considering decision makers (DMs) maybe hesitant among a set of values when determining the membership and non-membership degrees in a q-rung orthopair fuzzy environment, the q-rung dual hesitant fuzzy sets (q-RDHFS) were proposed.
Yuan Xu +5 more
doaj +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source