Results 101 to 110 of about 709,020 (315)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The 0-1 inverse maximum stable set problem [PDF]

Given an instance of a weighted combinatorial optimization problem and its feasible solution, the usual inverse problem is to modify as little as possible (with respect to a fixed norm) the given weight system to make the giiven feasible solution optimal.
Yerim Chung, Marc Demange
core  

Properties of solutions of optimization problems for set functions

International Journal of Mathematics and Mathematical Sciences, 2001
A definition of a special class of optimization problems with set functions is given. The existence of optimal solutions and first-order optimality conditions are proved.
Slawomir Dorosiewicz
doaj   +1 more source

Optimization instances for deterministic and stochastic problems on energy efficient investments planning at the building level

Data in Brief, 2015
Optimization instances relate to the input and output data stemming from optimization problems in general. Typically, an optimization problem consists of an objective function to be optimized (either minimized or maximized) and a set of constraints. Thus,
Emilio L. Cano, Javier M. Moguerza, Antonio Alonso-Ayuso   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Optimality conditions in set-valued optimization problems with respect to a partial order relation by using subdifferentials

, 2021
In this study, set-valued optimization problems are considered with respect to -order relation, which is a partial order relation on the family of nonempty and bounded sets. Four subdifferentials are defined for set-valued optimization maps.
Soyertem, Mustafa, Karaman, Emrah, Guvenc, Ilknur Atasever   +2 more
core   +1 more source

Sample size determination for training set optimization in genomic prediction. [PDF]

Theor Appl Genet, 2023
Wu PY, Ou JH, Liao CT.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assimilation of Matrix Operations with Picture Fuzzy Hypersoft Structures for Complex Decision Scenarios

International Journal of Computational Intelligence Systems
Matrices are a unifying concept that permeates diverse fields of study and provides a common framework for expressing and solving problems in all fields, including decision-making. In most decision-making scenarios, addressing uncertainty is paramount as
Muhammad Imran Harl, Muhammad Saeed, Muhammad Haris Saeed, Muhammad Salman Habib, Mehran Ullah   +4 more
doaj   +1 more source

Training Set Optimization for Sparse Phenotyping in Genomic Selection: A Conceptual Overview. [PDF]

Front Plant Sci, 2021
Isidro Y Sánchez J, Akdemir D.
europepmc   +1 more source