Results 91 to 100 of about 709,020 (315)

Improved approximation algorithms for optimization problems in graphs with superlogarithmic treewidth

, 2003
In this paper we present two novel generic schemes for approximation algorithms for optimization to partial k-trees. Our first scheme yields deterministic polynomialtime algorithms achieving typically an approximation factor of k/ log n, where k
Chlebikova, Janka, Lingas, Andrzej,, Artur Czumaj, Johan Nilsson, Czumaj, Artur, Andrzej Lingas, Czumaj, A, Nilsson, J, Nilsson, Johan, Miroslav Chlebík, Chlebik, Miroslav, Miroslav Chlebik (4461319), Lingas, Andrzej, Janka Chlebíková, Janka Chlebíková (16060964)   +14 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

First order optimality conditions in set-valued optimization [PDF]

A a set-valued optimization problem minC F(x), x 2 X0, is considered, where X0 X, X and Y are Banach spaces, F : X0 Y is a set-valued function and C Y is a closed cone.
Rocca Matteo, Ginchev Ivan, Crespi Giovanni P.   +2 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Strong Equivalence of Qualitative Optimization Problems

, 2012
We introduce the framework of qualitative optimization problems (or, simply, optimization problems) to represent preference theories. The formalism uses separate modules to describe the space of outcomes to be compared (the generator) and the preferences
Stefan Woltran, Truszczyński, Miroslaw, Woltran, Stefan, Faber, Wolfgang, Miroslaw Truszczynski, Wolfgang Faber   +5 more
core  

Extremality of Families of Sets and Set-Valued Optimization

Set-Valued and Variational Analysis
16 pages.
Nguyen Duy Cuong, Alexander Y. Kruger, Nguyen Hieu Thao   +2 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Continuous GRASP with a local active-set method for bound-constrained global optimization

, 2010
Global optimization, Stochastic methods, Active-set methods, Heuristic, CGRASP, GENCAN,
GOZZI, Erico M., Ernesto Birgin, Erico Gozzi, Ricardo Silva, BIRGIN, Ernesto G., RESENDE, Mauricio G. C., Mauricio Resende, SILVA, Ricardo M. A.   +7 more
core   +1 more source

A novel algorithmic multi-attribute decision-making framework for solar panel selection using modified aggregations of cubic intuitionistic fuzzy hypersoft set

Heliyon
To address the shortcomings of the cubic intuitionistic fuzzy sets (CIFSs) for the entitlement of multi-argument approximate function, the cubic intuitionistic fuzzy hypersoft set (Ω-set) is an emerging study area. This type of setting associates the sub-
Muhammad Sajid, Khuram Ali Khan, Atiqe Ur Rahman, Sanaa A. Bajri, Alhanouf Alburaikan, Hamiden Abd El-Wahed Khalifa   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source