Results 51 to 60 of about 797,844 (252)
On the Practical and Theoretical Possibility of Exploiting Science Fiction for Urban Planning
European Journal of Creative Practices in Cities and Landscapes, 2020 In recent years, cities and districts, such as Songdo City in South Korea, King Abdullah Economic City in Saudi Arabia, or Singapore, have been planned, built and rebuilt in adherence to the guiding principle of a “Smart City”.
Peter Klimczak
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The Journal of Engineering, 2019 Hybrid AC/DC distribution network has developed rapidly owing to its convenience for renewable energy integration, thus the authors are interested in quantifying the impact of uncertainty from renewable power on system static performance.
Jianing Gao +5 more
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SETNDS: A SET-Based Non-Dominated Sorting Algorithm for Multi-Objective Optimization Problems
Applied Sciences, 2020 Non-dominated sorting, used to find pareto solutions or assign solutions to different fronts, is a key but time-consuming process in multi-objective evolutionary algorithms (MOEAs).
Lingling Xue, Peng Zeng, Haibin Yu
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Application of Parzen Window estimation for incipient fault diagnosis in power transformers
High Voltage, 2018 Accurate faults diagnosis in power transformers is important for utilities to schedule maintenance and minimises the operation cost. Dissolved gas analysis (DGA) is one of the proven and widely accepted tools for incipient fault diagnosis in power ...
Md Mominul Islam +2 more
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