Results 71 to 80 of about 7,063,405 (274)

SETNDS: A SET-Based Non-Dominated Sorting Algorithm for Multi-Objective Optimization Problems

Applied Sciences, 2020
Non-dominated sorting, used to find pareto solutions or assign solutions to different fronts, is a key but time-consuming process in multi-objective evolutionary algorithms (MOEAs).
Lingling Xue, Peng Zeng, Haibin Yu
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modal Set Theory [PDF]

This article presents an overview of the basic philosophical motivations for, and some recent work in, modal set ...
Menzel, Christopher
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cultural heritage as a mathematical context: Interpretation of set theory in spatial layout of Prambanan temple

Infinity
Mathematics is often perceived as culturally neutral and detached from its social and historical foundations, leading to the neglect of cultural heritage rich in mathematical ideas.
Rully Charitas Indra Prahmana, Irma Risdiyanti, Nur Robiah Nofikusumawati Peni, Satoshi Kusaka, Khairullah Khairullah, Rahmi Ramadhani, Binti Anisaul Khasanah, Lekë Pepkolaj   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Application of Parzen Window estimation for incipient fault diagnosis in power transformers

High Voltage, 2018
Accurate faults diagnosis in power transformers is important for utilities to schedule maintenance and minimises the operation cost. Dissolved gas analysis (DGA) is one of the proven and widely accepted tools for incipient fault diagnosis in power ...
Md Mominul Islam, Gareth Lee, Sujeewa Nilendra Hettiwatte   +2 more
doaj   +1 more source

An approach to basic set theory and logic [PDF]

, 2013
The purpose of this paper is to outline a simple set of axioms for basic set theory from which most fundamental facts can be derived. The key to the whole project is a new axiom of set theory which I dubbed "The Law of Extremes".
Dydak, Jerzy
core