Results 81 to 90 of about 1,084,937 (314)
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Soft Intersection Quasi-interior Ideals of Semigroups
It has been shown that generalizing the ideals of an algebraic structure is both interesting and beneficial for mathematicians. In this context, the concept of quasi-interior (Ԛꟾ) ideal was introduced as a generalization of quasi-ideal and interior ideal
Sezgin, Aslıhan +1 more
core +1 more source
Mathematics is often perceived as culturally neutral and detached from its social and historical foundations, leading to the neglect of cultural heritage rich in mathematical ideas.
Rully Charitas Indra Prahmana +7 more
doaj +1 more source
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Applications of random set theory in econometrics
In recent years, the econometrics literature has shown a growing interest in the study of partially identified models, in which the object of economic and statistical interest is a set rather than a point.
Molchanov, Ilya, Molinari, Francesca
core +1 more source
The temperature dependence of the relaxation time of imidazolium perchlorate (Im-ClO4) was calculated from the pseudospin-phonon coupled (PS) and the energy fluctuation (EF) models close to the first-order phase transition temperature of 247 K.
A. Kiraci, Yurtseven, Hamit, N. Kara
core +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source

