Results 81 to 90 of about 7,063,405 (274)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
THE KAZAKH LANGUAGE HAS THE ASPECT CATEGORY IN ITS MATRIX
RUDN Journal of Language Studies, Semiotics and Semantics, 2019 The subject of the article is the absence of an aspect category, expressing main ideas of sentence propositions in the morphology of the Kazakh language and the conceptual confusion of the aspect category with tense category in the Kazakh language, which
Fazira A. Kakzhanova
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Georg Cantor i idea jedności nauki
Zagadnienia Filozoficzne w Nauce, 2009 G. Cantor presented - in an unpublished paper (1884) - a vision of the unity of science. He argued all sciences can be reduced directly to the set theory. A source of this idea was for Cantor the unity of mathematics (on the basis of set theory).
Jerzy Dadaczyński
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Formal methods in software development: A road less travelled
South African Computer Journal, 2010 An integration of traditional verification techniques and formal specifications in software engineering is presented. Advocates of such techniques claim that mathematical formalisms allow them to produce quality, verifiably correct, or at least highly ...
John A van der Poll
doaj
The Modal Status of Generative Principles
MetaphysicsThis contribution to a symposium marking the 30th anniversary of Kit Fine’s “Essence and Modality” raises a general question for essentialist theories of modality: What sort of proposition can figure in the essence of a property? Several versions of Fine’
Gideon Rosen
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source