Results 21 to 30 of about 93,479 (268)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mechanical Properties of Adjacent Pile Bases in Collapsible Loess under Metro Depot

Applied Sciences
Metro transit construction has begun to develop rapidly in northwest China because of the acceleration of urbanization. Accordingly, metro depots are also regarded as an essential auxiliary facility for stopping, operation, and maintenance of trains ...
Xiaohua Liu, Mingze Li, Hongjian Liao, Bingyan Huang, Shaohua Liu   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Coupling Analysis of “Demand–Satisfaction” for Rural Public Service Facilities Based on the Kano Model with Importance–Performance Analysis: A Case Study of Gaoqing County, Zibo City

Buildings
In the context of people-oriented and high-quality development, improving the quality of rural public service facilities is an important way to promote rural revitalization.
Xinlei Wang, Jinwei Wen, Jing He, Mengying Wang, Keju Liu, Jinghua Dai, Dingqing Zhang, Dian Zhou, Yingtao Qi   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Does proximity to tourist site affect the rental value of residential properties? Empirical evidence from Nigeria [PDF]

MATEC Web of Conferences, 2020
The property market plays a vital role in the economy of any nation. The industry provides jobs, investment opportunities and constructed space for productive activities, among others. Several authors have developed predictive models for the rental value
Oshodi Olalekan, Oyedeji Oyewale, Aigbovboa Clinton   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Study on the Perception of Local Characteristics in Cultural Street Vending Spaces, Taking Xi’an Baxian Temple as an Example

Buildings
The mode of urban renewal in China has changed from incremental expansion to a value-added stage, and the development of cities has increasingly focused on the human experience and quality improvement.
Yingtao Qi, Liping Yue, Tie Guo, Dian Zhou, Yulin Ren, Mengying Wang, Yujia Liu, Yujun Yang   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Assessment of the sedative effect of various anesthetics in Coregonus Peled (Gmelin, 1789) in aquaculture [PDF]

BIO Web of Conferences
The sedative effect of four anesthetic agents in whitefish was studied. It is shown that the effect of anesthetics causes a number of consistent behavioral and physiological reactions in fish, reflecting the change in the state of their body.
Tolmacheva Yulia, Borisova Elena, Dzyuba Elena, Sukhanova Lyubov, Nebesnykh Ivan, Demyanovich Inna, Demyanovich Konstantin   +6 more
doaj   +1 more source