Results 41 to 50 of about 1,332,882 (309)
No finer school than a settlement: the development of the educational settlement movement [PDF]
, 2002 No abstract ...
Freeman, M.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Research on the Vibration Fatigue Characteristics of Ancient Building Wood Materials
BuildingsIn this study, we selected ancient building timber as the research object. A series of static load tests were conducted to analyze the different performances of timber under tensile and compressive loads.
Chunyu Qian +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Cogent Social SciencesFemale-headed households (FHHs) constitute a heterogeneous social group with diverse resettlement housing needs, expectations, and aspirations. This study intends to expand knowledge on resettlement housing schemes using a gender lens.
Tharcille Dukuzemariya +2 more
doaj +1 more source
The Jewish 'ghetto': formation and spatial structure [PDF]
, 2001 Research into patterns of immigrant settlement has consistently indicated that certain areas of cities are prone to settlement by immigrant groups. This paper proposes that immigrant settlement of such areas may have a particular spacial pattern.
Penn, A, Vaughan, L
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Economies of scale and technological development in securities depository and settlement systems [PDF]
The paper investigates the existence and extent of economies of scale in depository and settlement systems. Evidence from 16 settlement institutions across different regions for the years 1993–2000 indicates the existence of significant economies of ...
Malkamäki, Markku +2 more
core +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source