Results 31 to 40 of about 10,655 (265)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Settlement Calculation Method for Composite Foundations Reinforced with Geo-Encased Stone Columns

open access: yesZhongwai Gonglu
Geo-encased stone columns (GESCs), known for their cost-effectiveness and simple construction, are widely employed in the reinforcement of soft soil foundations in practical engineering, and the analysis of their settlement serves as a crucial foundation
LONG Jun, TAN Jingpeng
doaj   +1 more source

A New Modified Peck Formula for Predicting the Surface Settlement Based on Stochastic Medium Theory

open access: yesAdvances in Civil Engineering, 2019
Peck method and stochastic medium method are the two most commonly used methods to estimate surface settlement caused by tunnel excavation. However, the Peck method was not suitable for a shallow-buried tunnel, and the calculation process of the ...
Zhanping Song, Xiaoxu Tian, Yuwei Zhang
doaj   +1 more source

STUDY ON THE DYNAMIC NUMERICAL ANALYSIS METHOD FOR THE SETTLEMENT OF FLEXIBLE PAVEMENT

open access: yesRudarsko-geološko-naftni Zbornik, 2019
In view of the problems of a single parameter of rock and soil materials, unclear boundary simulation and a simplified dynamic load in the current calculation of pavement settlement, the stochastic finite element-infinite element coupling method was ...
Xiao-yu Xu   +3 more
doaj   +1 more source

Pile-Soil Stress Ratio and Settlement of Composite Foundation Bidirectionally Reinforced by Piles and Geosynthetics under Embankment Load

open access: yesAdvances in Civil Engineering, 2021
The settlement calculation of composite foundation bidirectionally reinforced by piles and geosynthetics is always a difficult problem. The key to its accuracy lies in the determination of pile-soil stress ratio.
Binhui Ma   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Optimization Analysis of Settlement Parameters for Postgrouting Piles in Loess Area of Shaanxi, China

open access: yesAdvances in Civil Engineering, 2019
The settlement calculation of postgrouting piles is complex and depends on the calculation method and parameters. Static load tests were conducted to compare the settlement characteristics of nongrouting and postgrouting piles, and three vital parameters
Zhijun Zhou   +4 more
doaj   +1 more source

Settlement analysis of the large-dimensional shallow foundations founded on sand [PDF]

open access: yesMining and Metallurgy Engineering Bor
In practice, a number of methods have been developed for calculating the settlement of shallow foundations on sand, but in general it can be said that there is no standardized calculation method.
Rakić Dragoslav   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy