Results 41 to 50 of about 10,655 (265)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analytical computation of settlement displacement of buried pipeline caused by excavation

Shuiwen dizhi gongcheng dizhi
Excavation can induce the settlement deformation of adjacent buried pipeline. Obtaining the deformation is of great significance for evaluating the normal use and safety of pipeline.
Yulin LU, Jinze HE, Xiaoran CHEN, Li WANG   +3 more
doaj   +1 more source

Structural behaviour of masonry arch with no-horizontal springing settlement [PDF]

Fracture and Structural Integrity, 2018
This paper presents a calculation procedure for assessing the structural integrity of a masonry arch with non-horizontal springing settlement. By applying the Principle of Virtual Work (PVW) to the deformed arch system, the procedure proposed herein ...
P. Zampieri, N. Simoncello, C. Pellegrino   +2 more
doaj   +1 more source

The online monitoring system based on the laser distance measuring method for the settlement of transmission tower at the goaf of colliery

Xi'an Gongcheng Daxue xuebao, 2021
An online monitoring system based on the laser distance measuring method for the settlement of transmission tower at the goaf of colliery was put forward to deal with the common settlement and difficulty in monitoring.
Long ZHAO, Peng YUAN, Xiang ZHANG, Tiantang ZHENG   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Calculation Method of Ground Settlement Caused by Mechanical Construction in Metro-Connected Aisle

Buildings
Mechanical construction of metro-connected aisles is a novel construction method in the field of metro engineering, and it is being gradually applied to practical projects at present.
Yueqiang Duan, Maolei Wang, Jinghe Wang, Yuxiang Guo, Fa Chang, Boyuan Zhang, Weiyu Sun   +6 more
doaj   +1 more source

Settlement Characteristics of Split Grouting Pile Composite Foundation in Loess Areas

Advances in Civil Engineering, 2022
Loess foundations often affect the stability of superstructures due to their insufficient bearing capacities; thus, reinforcement measures are crucial for mitigating the uneven settlement of foundations.
Mingru Zhou, Lijun Xing, Yiming Chen, Hongxia Qiao   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Method of settlement calculation for underlying layer of soft soil composite foundation based on load transfer mechanism [PDF]

Archives of Civil Engineering
The mechanical properties of soil in soft soil area are poor, and the settlement of the underlying layer in the composite foundation accounts for a large proportion of the total settlement.
Yaoting Xiao, Jing Wang
doaj   +1 more source