Results 41 to 50 of about 8,548 (258)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Data-Supported Prediction of Surface Settlement Behavior on Opencast Mine Dumps Using Satellite-Based Radar Interferometry Observations

Mining
To ensure the safe repurposing of post-mining landscapes, understanding and managing geotechnical risks, particularly ground movements such as settlements on opencast mining dump surfaces, is critical.
Jörg Benndorf, Natalie Merkel, Andre John   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Clayshock mechanism and application to shield tunneling through existing tunnels: Settlement prediction using artificial intelligence

Journal of Intelligent Construction
In this study, we investigated the mechanism of clayshock during the construction of a new shield tunnel that passes through an existing shield tunnel.
Zhiqiang Bai, Yusheng Jiang, Chenzhong Jing, Zhiyong Yang   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Multi-Point Seawall Settlement Prediction with Limited Data Volume Using an Improved Fractional-Order Grey Model

Fractal and Fractional
Settlement prediction based on monitoring data holds significant importance for engineering maintenance of seawalls. In practical engineering, the volume of the collected monitoring data is often limited due to the restrictions of devices and engineering
Peng Qin, Chunmei Cheng, Zhenzhu Meng, Chunmei Ding, Sen Zheng, Huaizhi Su   +5 more
doaj   +1 more source

Prediction of Square Footing Settlement under Eccentric Loading on Gypseous Soil through Proposed Surface for Dry and Soaked States [PDF]

Engineering and Technology Journal, 2013
Gypseous soils as any other soils deform under loading, this deformation differs greatly between its dry state and its soaked state. This deformation also differs when the loading is applied with eccentricity.An experimental work was conducted on a ...
Bushra S. Z. Albusoda, Abdul-Kareem E, R. S.Hussein   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Analysis and Warning Prediction of Tunnel Deformation Based on Multifractal Theory

Fractal and Fractional
To better analyze the fluctuation characteristics and development law of tunnel deformation data, multifractal theory is applied to tunnel deformation analysis.
Chengtao Yang, Rendong Huang, Dunwen Liu, Weichao Qiu, Ruiping Zhang, Yu Tang   +5 more
doaj   +1 more source