Results 61 to 70 of about 8,548 (258)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Prediction of Soft Soil Settlement Based on Ensemble Smoother with Multiple Data Assimilation

Applied Sciences
The selection of soil parameters relies heavily on the engineering experience of practitioners and frequently results in settlement predictions that deviate from field monitoring, especially for soft soil foundations.
Pan Zhao, Zeling Zhou, Delian Ma, Xiaodong Pan, Fan Wu, Mingyuan Wang   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Machine Learning-Based Measurement and Prediction of Ground Settlement Induced by Shield Tunneling Undercrossing Existing Tunnels in Composite Strata

Sensors
To address the issue of insufficient accuracy in traditional settlement prediction methods for shield tunneling undercrossing in composite strata in Hangzhou, this paper proposes a particle swarm optimization (PSO)-based Bidirectional Long Short-Term ...
Mei Dong, Mingzhe Guan, Kuihua Wang, Yeyao Wu, Yuhan Fu   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Identification and Prediction Inversion of Mining Area Subsidence by Integrating SBAS-InSAR and EMD-ARIMA Model

IEEE Access
Due to the use of heavy industry equipment and frequent mining activities, the rock strata and the surface of Dexing Copper Mine were prone to settlement and deformation. In order to accurately analyze the time series settlement variation of the surface,
Haiping Xiao, Yiqiang Xia, Yongchao Fan, Lanlan Chen, Rongping Duan   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Mechanism-Driven Intelligent Settlement Prediction for Shield Tunneling Through Areas Without Ground Monitoring

Smart Cities
Ground settlement is a crucial indicator for assessing the safety of shield tunneling and its impact on the surrounding environment. However, most existing settlement prediction methods are based on historical data, which can only be applied with ...
Min Hu, Pengpeng Zhao, Jing Lu, Bingjian Wu   +3 more
doaj   +1 more source

Prediction of Ground Settlements Associated with Shield Tunnelling

Soils and Foundations, 1978
There is much uncertainty to estimate the ground settlement associated with shield tunnelling due to the complicatedly interacted conditions between tunnelling methods and soil characteristics. Accordingly, if the shape of the ground settlement could be quantitatively predicted, it would be very effective for the assessment of its influence on the ...
YOSHIKOSHI, WATARU, WATANABE, OSAMU, TAKAGI, NOBUO   +2 more
openaire   +2 more sources

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source