Results 171 to 180 of about 2,895 (208)

Survival in end stage renal disease: calcium carbonate vs. sevelamer

Journal of Clinical Pharmacy and Therapeutics, 2007
There is concern regarding long-term excess calcium intake in end-stage renal disease populations. Because calcium carbonate is an over-the-counter (OTC) medication, few studies have been able to track its use. The Veterans Health Administration (VA) tracks national pharmacy data for both OTC and prescription drugs.
A M, Borzecki, A, Lee, S W, Wang, L, Brenner, L E, Kazis   +4 more
openaire   +2 more sources

Buffering Effects of Calcium Carbonate as Clarified by Sevelamer Hydrochloride Monotherapy

Therapeutic Apheresis and Dialysis, 2008
Abstract:  This study was undertaken to examine the necessity of taking into account the acid–base balance to ensure safe switching from calcium carbonate to sevelamer hydrochloride in hemodialysis patients. Forty‐two hemodialysis patients were divided into two groups: the sevelamer hydrochloride therapy group (n = 18; “monotherapy group”) and the ...
Toshio, Akatsuka, Toshio, Mochizuki, Takao, Koike   +2 more
openaire   +2 more sources

Sevelamer Carbonate Reduces Inflammation and Endotoxemia in an Animal Model of Uremia

Blood Purification, 2010
<i>Background:</i> Renal failure is associated with activation of inflammatory response, but the mechanisms behind this observation and potential anti-inflammatory strategies are yet to be defined. Endotoxin (ET) translocation from the intestinal lumen can potentially trigger systemic inflammatory response, and ET binding represents a ...
Aline B, Hauser, Iuly R F, Azevedo, Simone, Gonçalves, Andréa, Stinghen, Carlos, Aita, Roberto, Pecoits-Filho   +5 more
openaire   +2 more sources

Sevalamer Hydrochloride, Sevelamer Carbonate and Lanthanum Carbonate: In Vitro and In Vivo Effects on Gastric Environment

Therapeutic Apheresis and Dialysis, 2015
AbstractHyperphosphatemia is common in patients with chronic renal failure. Phosphate binders are associated with gastric intolerance, representing the main reason of drug discontinuation. The aim of this study was to compare the effects in vitro and in vivo of sevelamer hydrochloride (SH), sevelamer carbonate (SC) and lanthanum carbonate (LC) on ...
COPPOLINO, GIUSEPPE, LUCISANO, SILVIA, Rivoli, Laura, Fuiano, Giorgio, VILLARI, Antonino Gaet., VILLARI, IOLE, LEONELLO, Grazia, LACQUANITI, ANTONIO, SANTORO, Domenico, BUEMI, Michele   +9 more
openaire   +3 more sources

In-vitro Equilibrium Phosphate Binding Study of Sevelamer Carbonate by UV-Vis Spectrophotometry

Drug Research, 2018
AbstractSevelamer carbonate is a cross-linked polymeric amine; it is the active ingredient in Renvela® tablets. US FDA provides recommendation for demonstrating bioequivalence for the development of a generic product of sevelamer carbonte using in-vitro equilibrium binding study.
Budi, Prasaja, M Maulana, Syabani, Endah, Sari, Uci, Chilmi, Prawitasari, Cahyaningsih, Theresia Weliana, Kosasih   +5 more
openaire   +2 more sources

Relative in Vitro Efficacy of the Phosphate Binders Lanthanum Carbonate and Sevelamer Hydrochloride

Journal of Pharmaceutical Sciences, 2007
The high tablet burden and poor compliance associated with phosphate-binding drugs has led to a search for more potent agents. In vitro-binding studies were performed on the recently introduced binder, lanthanum carbonate (LC; Fosrenol), to compare its phosphate-binding affinity with sevelamer hydrochloride (SH; Renagel).
Autissier V, Damment SJP, Henderson RA
openaire   +3 more sources

Multifaceted skeletal effects of sevelamer carbonate in a secondary hyperparathyroidism model

Endocrine
Hyperphosphatemia leads to abnormal mineralization of bones and soft tissues in patients with chronic kidney disease-induced secondary hyperparathyroidism (CKD-SHPT). Sevelamer lowers phosphate levels by binding to dietary phosphate in the gastrointestinal system, forming new bone and reducing the risk of renal osteodystrophy and fracture. However, the
Shivani, Sharma, Saroj, Kumar, Manendra Singh, Tomar, Divya, Chauhan, Sreyanko, Sadhukhan, Chirag, Kulkarni, Swati, Rajput, Konica, Porwal, Rajdeep, Guha, Ashutosh, Shrivastava, Jiaur R, Gayen, Navin, Kumar, Naibedya, Chattopadhyay   +12 more
openaire   +2 more sources

Effects of Calcium Carbonate, Sevelamer Hydrochloride or Pantoprazole on the Pharmacokinetics of Cinacalcet

Clinical Drug Investigation, 2014
Secondary hyperparathyroidism is a common consequence of chronic kidney disease. Cinacalcet (Sensipar(®)) is often prescribed in combination to reduce elevated levels of parathyroid hormone, calcium and phosphorus. The objective of this study was to assess the effects of concomitantly administered therapies of calcium carbonate (CaCO(3); TUMS ...
Desmond, Padhi, Robert, Harris, John T, Sullivan   +2 more
openaire   +2 more sources

DETERMINATION OF RESIDUAL CHLORIDE IN SEVELAMER CARBONATE USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Journal of Liquid Chromatography & Related Technologies, 2013
Sevelamer carbonate is the active ingredient of Renvela tablets; a cross-linked polymeric amine that binds phosphate. It was developed as a pharmaceutical alternative to sevelamer hydrochloride (Renagel). Renvela is indicated for the control of hyperphosphatemia in patients with end-stage renal disease (ESRD).
Kumarswamy Ummiti, Kalyan Reddy Chennuru, Sudhakar Vakkala, Venugopal Dama, Malleswara Reddy Annarapu   +4 more
openaire   +1 more source

Lanthanum-carbonate/sevelamer

Reactions Weekly, 2023
openaire   +1 more source