Results 1 to 10 of about 56,993 (185)
Pre-treatment of dairy and breast milk with sevelamer hydrochloride and sevelamer carbonate to reduce phosphate. [PDF]
Perit Dial Int, 2013 Introduction Young children and infants with chronic kidney disease are at increased risk of hyperphosphatemia because of high intake of dairy products. Hyperphosphatemia leads to metastatic calcifications and an increased risk of cardiovascular complications.
Raaijmakers R +4 more
europepmc +6 more sources
Kinetic and Thermodynamic Evaluation of Phosphate Ions Binding Onto Sevelamer Hydrochloride [PDF]
International Journal of Pharmaceutics, 2014 Sevelamer hydrochloride is the first non-aluminium, non-calcium-based phosphate binder developed for the management of hyperphosphatemia in end stage renal diseases. It is a synthetic ion-exchange polymer which binds and removes phosphate ions due to the high content of cationic charge associated with protonated amine groups on the polymer matrix. This
Peter McLoughlin +2 more
exaly +5 more sources
A Randomized, Crossover Design Study of Sevelamer Carbonate Powder and Sevelamer Hydrochloride Tablets in Chronic Kidney Disease Patients on Haemodialysis. [PDF]
Nephrology Dialysis Transplantation, 2009 Background. Sevelamer carbonate is an improved, buffered form of sevelamer hydrochloride developed for the treatment of hyperphosphataemia in CKD patients.
Stanley L-S Fan, Sandip Mitra
exaly +4 more sources
Use of sevelamer hydrochloride as an oxalate binder. [PDF]
J Urol, 2008 We tested the hypothesis that the cationic phosphate binder sevelamer hydrochloride could reduce hyperoxaluria and calcium oxalate supersaturation in patients with enteric hyperoxaluria by binding fatty acids, binding phosphate and rendering calcium free to bind oxalate, and/or directly binding oxalate.
Lieske JC, Regnier C, Dillon JJ.
europepmc +4 more sources
Acid Loading During Treatment With Sevelamer Hydrochloride: Mechanisms and Clinical Implications [PDF]
Kidney International, 2004 Short-term and long-term studies indicate that patients treated with sevelamer hydrochloride have lower serum bicarbonate levels than patients treated with calcium-containing phosphate binders. This observation has previously been attributed to withdrawal of a source of base with discontinuation of calcium carbonate or calcium acetate.
Charles R Nolan, Wajeh Y Qunibi
exaly +3 more sources
The Effects of Sevelamer Hydrochloride and Calcium Carbonate on Kidney Calcification in Uremic Rats [PDF]
Journal of the American Society of Nephrology, 2002 The control of serum phosphorus (P) and calcium-phosphate (Ca x P) product is critical to the prevention of ectopic calcification in chronic renal failure (CRF). Whereas calcium (Ca) salts, the most commonly used phosphate binders, markedly increase serum Ca and positive Ca balance, the new calcium- and aluminum-free phosphate binder, sevelamer ...
M. Cozzolino +6 more
openaire +5 more sources
Renal Failure, 2005 Reports on acid-base side effects of sevelamer hydrochloride (SH), a new aluminum (Al)- and calcium (Ca)-free phosphate binder are rare and conflicting. In a retrospective analysis, we evaluated SH impact on metabolic acidosis and serum potassium (K) in hemodialysis (HD) patients. Two groups of stable HD patients were studied.
Macroui A, Sonikian +5 more
exaly +3 more sources
Evaluation of the In Vitro Efficacy of Sevelamer Hydrochloride and Sevelamer Carbonate [PDF]
Journal of Pharmaceutical Sciences, 2016 The objective of this project is to develop an in vitro approach that can be used to determine the phosphate binding capacity of sevelamer hydrochloride and carbonate for both drug products and active pharmaceutical ingredients (APIs). A simple and efficient inductively coupled plasma spectrometer method for analysis of phosphate at physiologically ...
Yongsheng, Yang +5 more
openaire +2 more sources
Process Validation of Sevelamer Hydrochloride Film Coated Tablet
International Journal of Medical Sciences and Pharma Research, 2022 All the three batches resulted in granules with desired flow and compaction which is evident from the data of compressed tablets. At compression stage Weight parameters and Speed parameters evaluated and found within Specified limit as well as, The Statistical analysis process performance is high capable, Data is normal and Z bench value also give ...
Basant Kumar Yadav +3 more
openaire +2 more sources
Sevelamer hydrochloride use in a toddler
Nihon Toseki Igakkai Zasshi, 2005 塩酸セベラマーは非吸収性のリン (P) 吸着ポリマーである. 血清カルシウム (Ca) 濃度を上昇させることなく血清P値の低下が期待できるため成人領域では広く使用されているが, 小児における報告は少なく, 2歳以下の乳幼児における報告はない. 1歳8か月の女児に対して塩酸セベラマーを投与したので, 報告する.症例は右腎無形成および左低形成腎のため腎不全となり, 生後9か月時, 腹膜透析 (PD) に導入した. 保存期より高P血症, 高Ca血症を認め腎性くる病を合併していたが, 活性型ビタミンD3製剤およびカルシウム製剤の投与は困難であった. PD開始後も血清Ca値, 血清P値のコントロールは得られず, Ca×P積高値が持続した. 短期的なアルミニウムゲル製剤を使用した後, 塩酸セベラマーを投与した.
Nakashima, Taiji +8 more
openaire +2 more sources