Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Study analytical function subordination properties by applying a novel linear operator. [PDF]
Majel MS, Hameed MI.
europepmc +1 more source
Book Review: Entire holomorphic mappings in one and several complex variables [PDF]
David Drasin
openalex +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Is structural equation modeling applicable in a population health determinants assessment? An experience from the European Union. [PDF]
Jankowiak M, Rój J.
europepmc +1 more source
Convex mappings in several complex variables
Hidetaka Hamada, Gabriela Kohr
openalex +1 more source
Entire functions of several complex variables satisfying certain Fermat-type PDDEs [PDF]
Hong Yan Xu, Rajib Mandal, Raju Biswas
openalex +1 more source
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Machine Learning and Abdominal Aortic Aneurysm: A New Paradigm in Prediction and Prognosis after Endovascular Aneurysm Repair. [PDF]
Nishibe T +6 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source

