Results 101 to 110 of about 657,398 (291)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Rhabdomyolysis as Potential Late Complication Associated with COVID-19

Emerging Infectious Diseases, 2020
We describe a patient in Wuhan, China, with severe acute respiratory syndrome coronavirus 2 infection who had progressive pulmonary lesions and rhabdomyolysis with manifestations of lower limb pain and fatigue.
Min Jin, Qiaoxia Tong
doaj   +1 more source

Severe acute respiratory syndrome and Toronto [PDF]

Journal of Epidemiology and Community Health, 2003
Early detection and isolation of suspected cases is the key “I hold my breath in elevators even empty ones”.1 This was the view of one Toronto resident I read in a local newspaper in late April this year. I had just joined, as an observer, the Federal Emergency Operations Centre that had been activated by Health Canada to coordinate efforts to contain
openaire   +2 more sources

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

T Cell responses to whole SARS Coronavirus in humans [PDF]

, 2008
Effective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs.
Douek, Daniel C., McMichael, A., Temperton, Nigel J., Lin, C.L., Tran, Bac-Hai, Brenchley, JM, Screaton, Gavin R., Yan, Huiping, Yan, H., Tran, BH, Douek, DC, Ma, Shiwu, Temperton, N., Li, Chris Ka-fai, Wu, H., Wu, Hao, Hou, Jin-lin, Yan, H, Xu, XN, Ma, S., Tran, H., Screaton, GR, Mongkolsapaya, J., Mongkolsapaya, Juthathip, McMichael, Andrew J., Ma, S, Tang, X., Weiss, R., Xu, X., Hou, JL, Wang, L., Li, C., Tang, X, Zhang, Mingxia, Weiss, RA, Wang, L, Lin, Chen-lung Steve, Weiss, Robin A., Screaton, G., Mcmichael, AJ, Lin, CL, Hou, J., Wu, H, Mcmichael, Andrew, Xu, Xiao-Ning, Brenchley, J., Brenchley, Jason M., Mongkolsapaya, J, Wang, Lili, Douek, D., Tang, Xiaoping, Li, CK, Zhang, M, Temperton, NJ, Zhang, M.   +54 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Atypical SARS in Geriatric Patient

Emerging Infectious Diseases, 2004
We describe an atypical presentation of severe acute respiratory syndrome (SARS) in a geriatric patient with multiple coexisting conditions. Interpretation of radiographic changes was confounded by cardiac failure, with resolution of fever causing ...
Augustine K.H. Tee, Helen M.L. Oh, K.P. Hui, Christopher T.C. Lien, K. Narendran, B.H. Heng, A.E. Ling   +6 more
doaj   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Precautionary behavior in response to perceived threat of pandemic influenza. [PDF]

, 2007
Faced with an epidemic of an infectious disease, persons may take precautionary actions to try to reduce their risk. Such actions include avoiding situations that persons perceive to be risky, which can have negative health and economic effects ...
Sadique, M. Zia, Edmunds, W. John, de Zwart, Onno, Philippe Beutels, Onno de Zwart, M. Zia Sadique, Smith, Richard D, Meerding, William Jan, William Jan Meerding, Edmunds, W John, Beutels, Philippe, W. John Edmunds, Brug, Johannes, Johannes Brug, Richard D. Smith, Smith, Richard, Sadique, M Zia   +16 more
core   +1 more source