Results 251 to 260 of about 3,688,287 (401)

Severe Asthma Exacerbations: From Risk Factors to Precision Management Strategies. [PDF]

J Clin Med
Paredes M, Osorio J, García de la Fuente A, Rodríguez E, Picado C, Ojanguren I, Arismendi E.   +6 more
europepmc   +1 more source

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Epithelial-derived cytokines in the pathogenesis of severe asthma. [PDF]

Front Allergy
Pham DD, Kim TB.
europepmc   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source

The role of pulmonary rehabilitation in severe asthma: a comprehensive review. [PDF]

Front Med (Lausanne)
Guarnieri G, Pozza M, Vianello A.
europepmc   +1 more source

Anti-IgE: lessons from clinical trials in patients with severe allergic asthma symptomatic despite optimised therapy

, 2007
Roland Buhl
openalex   +1 more source

Clinical Impact of Mepolizumab on Airway Mucus Plugs in Patients with Severe Asthma. [PDF]

J Asthma Allergy
Hara Y, Tanabe N, Marumo S, Murohashi K, Hayashi Y, Nagata M, Asada T, Nagaoka S, Kobayashi N, Hirai T, Kaneko T.   +10 more
europepmc   +1 more source

Ultra‐refractory epilepsy: The newly described entity

Epilepsia Open, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) is defined as the failure of two antiseizure medications (ASMs) to achieve complete seizure control, affecting approximately 30% of epilepsy patients. In some cases, additional ASMs and surgical approaches are also unsuccessful.
Jan Vinklárek, Petra Búřilová, Mojdeh Raouf Zadeh, Eva Zatloukalová, Jitka Kočvarová, Ondřej Strýček, Martin Pail, Klára Štillová, Jan Chrastina, Eva Brichtová, Andrea Pokorná, Dana Mazánková, Milan Brázdil, Irena Doležalová   +13 more
wiley   +1 more source

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, EarlyView.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source