Results 251 to 260 of about 2,200,340 (304)

Unrecognized ciliary motility disorders in neutrophilic severe asthma exacerbations. [PDF]

Allergy Asthma Clin Immunol
Thawanaphong S, Gonzalez-Bravo L, Radford K, Kjarsgaard M, Venegas Garrido C, Fedosenko S, Ho T, Dyment L, Tan NS, Zhang K, Adatia A, Mukherjee M, Dolovich M, Nair P.   +13 more
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Impact of Overweight and Obesity in Severe Asthma Patients and Its Influence on Achieving Clinical Remission. [PDF]

J Asthma Allergy
Al-Ahmad M, Ali A, Talat W.
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Small airway dysfunction as a functional barrier to spirometry-defined clinical remission in severe asthma treated with biologic therapies. [PDF]

World Allergy Organ J
Al-Ahmad M, Ali A, Talat W.
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IL-5 blockade restores the bronchial epithelium and attenuates airway remodelling in severe asthma

Zanin O, Eminton AJ, Freydina D, Kanabar-Raivadera V, Drummond I, Horton K, Phillips J, Dhillon R, Naftel J, Soe W, Dennison P, Lau L, Ward J, Blume C, Swindle EJ, Martinez-Nunez RT, Rupani H.   +16 more
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Severe Asthma

Clinical Reviews in Allergy & Immunology, 2003
Severe asthma is a term that is commonly used to describe patients with refractory, brittle, near fatal, and difficult-to-control asthma. Patients with severe asthma typically experience persistent symptoms despite medical therapy, report decreased quality of life and suffer an accelerated loss of lung function.
Nicholas J, Kenyon, Nizar N, Jarjour
openaire   +2 more sources

Severe Asthma in Childhood

Immunology and Allergy Clinics of North America, 2019
Severe asthma is broadly defined as asthma requiring a high level of therapy, usually high doses of inhaled corticosteroids, to bring under control. Children who remain symptomatic despite such treatment are a heterogeneous population, and bear a high burden of disease and require high resource utilization.
Angela, Marko, Kristie R, Ross
openaire   +2 more sources

Immunopathogenesis of Severe Asthma

Current Pharmaceutical Design, 2011
Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology.
Brightling, CE, Gupta, S, Hollins, F, Sutcliffe, A, Amrani, Y   +4 more
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Exacerbations of severe asthma

Clinical & Experimental Allergy, 2012
SummaryExacerbations occur frequently in severe asthma. They result in significant morbidity and can lead to hospitalization and death. Severe exacerbations can also lead to an accelerated decline in lung function. Phenotyping severe asthma can aid with both prognostication of exacerbation risk and maintenance treatment selection to minimize future ...
McDonald, V. M., Gibson, P. G.
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Biologics in severe asthma

Minerva Medica, 2022
Asthma is a chronic airway disease consisting of usually variable airflow limitation and bronchial hyperresponsiveness. Many different phenotypes characterize the clinical expression of asthma, determined by heterogeneous inflammatory patterns driven by distinct cellular and molecular mechanisms known as endotypes.
Pelaia, Corrado, Pelaia, Giulia, Crimi, Claudia, Longhini, Federico, Lombardo, Nicola, Savino, Rocco, Sciacqua, Angela, Vatrella, Alessandro   +7 more
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Pathogenesis of severe asthma

Clinical & Experimental Allergy, 2012
SummaryPatients with severe asthma have asthma symptoms which are difficult to control, require high dosages of medication, and continue to experience persistent symptoms, asthma exacerbations or airflow obstruction. Epidemiological and clinical evidences point to the fact that severe asthma is not a single phenotype.
A H, Poon, D H, Eidelman, J G, Martin, C, Laprise, Q, Hamid   +4 more
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