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Minerva Medica, 2022
Asthma is a chronic airway disease consisting of usually variable airflow limitation and bronchial hyperresponsiveness. Many different phenotypes characterize the clinical expression of asthma, determined by heterogeneous inflammatory patterns driven by distinct cellular and molecular mechanisms known as endotypes.
Pelaia, Corrado +7 more
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Asthma is a chronic airway disease consisting of usually variable airflow limitation and bronchial hyperresponsiveness. Many different phenotypes characterize the clinical expression of asthma, determined by heterogeneous inflammatory patterns driven by distinct cellular and molecular mechanisms known as endotypes.
Pelaia, Corrado +7 more
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Clinical Reviews in Allergy & Immunology, 2003
Severe asthma is a term that is commonly used to describe patients with refractory, brittle, near fatal, and difficult-to-control asthma. Patients with severe asthma typically experience persistent symptoms despite medical therapy, report decreased quality of life and suffer an accelerated loss of lung function.
Nicholas J. Kenyon, Nizar N. Jarjour
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Severe asthma is a term that is commonly used to describe patients with refractory, brittle, near fatal, and difficult-to-control asthma. Patients with severe asthma typically experience persistent symptoms despite medical therapy, report decreased quality of life and suffer an accelerated loss of lung function.
Nicholas J. Kenyon, Nizar N. Jarjour
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The Lancet, 1998
peribronchial tissues. Eosinophilic myocarditis is a rare feature observed in various clinical situations; it can be isolated and idiopathic, or induced by drugs (such as antibiotics and carbamazepine). By contrast, the association of eosinophilic myocarditis with severe bronchial asthma, an eosinophil count of more than 10%, and history of severe food
RABUSIN M +3 more
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peribronchial tissues. Eosinophilic myocarditis is a rare feature observed in various clinical situations; it can be isolated and idiopathic, or induced by drugs (such as antibiotics and carbamazepine). By contrast, the association of eosinophilic myocarditis with severe bronchial asthma, an eosinophil count of more than 10%, and history of severe food
RABUSIN M +3 more
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British Journal of Diseases of the Chest, 1978
Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
D. J. Maberly +4 more
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Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
D. J. Maberly +4 more
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Immunopathogenesis of Severe Asthma
Current Pharmaceutical Design, 2011Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology.
Brightling, CE +4 more
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Immunology and Allergy Clinics of North America, 2019
Severe asthma is broadly defined as asthma requiring a high level of therapy, usually high doses of inhaled corticosteroids, to bring under control. Children who remain symptomatic despite such treatment are a heterogeneous population, and bear a high burden of disease and require high resource utilization.
Angela Marko, Kristie R. Ross
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Severe asthma is broadly defined as asthma requiring a high level of therapy, usually high doses of inhaled corticosteroids, to bring under control. Children who remain symptomatic despite such treatment are a heterogeneous population, and bear a high burden of disease and require high resource utilization.
Angela Marko, Kristie R. Ross
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Severe Exacerbations of Asthma
Critical Care Nursing Quarterly, 2004All asthmatics regardless of their perceived severity, are at risk of exacerbation, particularly if they are suboptimally treated in the outpatient arena. Fortunately most patients recover after administration of bronchodilators and anti-inflammatory medications, but preventable deaths continue to occur and refractory cases result in hospitalization ...
Susan J. Corbridge, Thomas C. Corbridge
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Clinical & Experimental Allergy, 2012
SummaryPatients with severe asthma have asthma symptoms which are difficult to control, require high dosages of medication, and continue to experience persistent symptoms, asthma exacerbations or airflow obstruction. Epidemiological and clinical evidences point to the fact that severe asthma is not a single phenotype.
Catherine Laprise +4 more
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SummaryPatients with severe asthma have asthma symptoms which are difficult to control, require high dosages of medication, and continue to experience persistent symptoms, asthma exacerbations or airflow obstruction. Epidemiological and clinical evidences point to the fact that severe asthma is not a single phenotype.
Catherine Laprise +4 more
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Rhinosinusitis in severe asthma
Journal of Allergy and Clinical Immunology, 2001Chronic rhinosinusitis is a common comorbidity of asthma. However, sinonasal involvement in severe steroid-dependent asthma is still undefined.The aim of the study was to evaluate chronic rhinosinusitis in 35 patients with severe steroid-dependent asthma by using a clinical score and coronal computed tomography (CT) scanning.Thirty-five subjects (16 ...
Hélène Vernhet +7 more
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Journal of Allergy and Clinical Immunology, 2006
Severe asthma represents less than 10% of all asthma, but these patients are responsible for a disproportionate share of the health care costs and morbidity associated with the disease. A significant challenge in the diagnosis and management of severe asthma is the ability to identify accurately the patients most at risk for adverse outcomes, such as ...
Stephen P. Peters, Wendy C. Moore
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Severe asthma represents less than 10% of all asthma, but these patients are responsible for a disproportionate share of the health care costs and morbidity associated with the disease. A significant challenge in the diagnosis and management of severe asthma is the ability to identify accurately the patients most at risk for adverse outcomes, such as ...
Stephen P. Peters, Wendy C. Moore
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