Results 241 to 250 of about 287,217 (298)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

The therapeutic use of osmotic minipumps in the severe combined immunodeficiency (SCID) mouse model for rheumatoid arthritis

, 2008
Anette Knedla, Birgit Riepl, Stephanie Lefèvre, S Kistella, Joachim Grifka, Rainer H. Straub, Steffen Gay, Jürgen Schölmerich, Ulf Müller‐Ladner, Elena Neumann   +9 more
openalex   +1 more source

Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study

Molecular Nutrition &Food Research, EarlyView.
We evaluated the impact of food matrix on Lacticaseibacillus rhamnosus CRL1505 survival and total quantification, carried out with strain‐specific approaches. Our results confirmed (i) the remarkable ability of CRL1505 to withstand harsh gastrointestinal conditions and (ii) the protective effect of the food matrix.
Nicola Mangieri, Viola Termine, Giorgio Gargari, Nicolò Fornasari, Michele Isotti, Susana Salva, Julio Villena, María Pía Taranto, Valentina Taverniti, Susana Álvarez, Graciela Font, Ylenia Zanchetta, Stefania Arioli, Diego Mora   +13 more
wiley   +1 more source

Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized 129Xe lung MRI

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose Reduced signal‐to‐noise ratio (SNR) in hyperpolarized 129Xe MR images can affect accurate quantification for research and diagnostic evaluations. Thus, this study explores the application of supervised deep learning (DL) denoising, traditional (Trad) and Noise2Noise (N2N) and unsupervised Noise2void (N2V) approaches for 129Xe MR ...
Abdullah S. Bdaiwi, Matthew M. Willmering, Riaz Hussain, Erik Hysinger, Jason C. Woods, Laura L. Walkup, Zackary I. Cleveland   +6 more
wiley   +1 more source

Monoclonal IgG Kappa gammopathy previous to hematopoietic stem cell transplantation in an infant with severe combined immunodeficiency

, 2012
Inês Simão, Ana Isabel Cordeiro, Luís Miguel Borrego, Catarina Martins, Conceição Neves, João Farela Neves   +5 more
openalex   +2 more sources

A Comprehensive Study of Quantum Dots: Ranging From Synthesis to Applications in Electrochemical Biosensors in the Detection of Biomolecules, Gastrointestinal Diseases, and Electrophysiology

Nano Select, EarlyView.
Quantum dots (QDs) typically refer to extremely small semiconductor particles, often no larger than 10 nm. The development of efficient biosensors for the sensitive and selective detection of biomolecules is essential for fundamental research in analytical chemistry, biomedicine, clinical diagnosis, and electrophysiology.
Parisa Navid, Hamid Reza Akbari‐Hasanjani, Reza Akbari‐Hasanjani   +2 more
wiley   +1 more source

Recommendations for Screening and Management of Late Effects in Patients with Severe Combined Immunodeficiency after Allogenic Hematopoietic Cell Transplantation: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT

, 2017
Jennifer Heimall, Rebecca H. Buckley, Jennifer M. Puck, Thomas A. Fleisher, Andrew R. Gennery, Élie Haddad, Bénédicte Neven, Mary Slatter, Skinner Roderick, K. Scott Baker, Andrew C. Dietz, Christine Duncan, Linda M. Griffith, Luigi D. Notarangelo, Michael A. Pulsipher, Morton J. Cowan   +15 more
openalex   +2 more sources

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Clinical characteristics and risk factors of severe bocavirus‐positive pneumonia in children and a literature review

Pediatric Discovery, EarlyView.
The study explored the clinical characteristics and risk factors of HBoV‐positive severe pneumonia in children. These findings indicate that HBoV can be identified in respiratory samples from children with severe pneumonia, denoting its role as a viral pathogen in hospitalized children with this condition.
Jing Liao, Zhongying Yang, Yu He, Jianhua Wei, Luo Ren, Enmei Liu, Na Zang   +6 more
wiley   +1 more source

Fatal viscerotropic and neurotropic disease after yellow fever vaccine: a rare manifestation leading to diagnosis of severe combined immunodeficiency in an infant. [PDF]

Rev Inst Med Trop Sao Paulo
Vieira LJT, Goebel GA, Barcelos Y, Cunha LO, Santos LTM, Romanelli RMC, Minafra FG, Carvalho AL, Carvalho LFA, Diniz LMO.   +9 more
europepmc   +1 more source