Results 41 to 50 of about 501,602 (328)

Mixed models for longitudinal left-censored repeated measures [PDF]

open access: yesComput Methods Programs Biomed 74, 3 (06/2004) 255-60, 2007
Longitudinal studies could be complicated by left-censored repeated measures. For example, in Human Immunodeficiency Virus infection, there is a detection limit of the assay used to quantify the plasma viral load. Simple imputation of the limit of the detection or of half of this limit for left-censored measures biases estimations and their standard ...
arxiv   +1 more source

Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real‐world cohort study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objective A substantial part of central nervous system (CNS) disorders remains unexplained, despite various new and minimally invasive diagnostic techniques. Within this rapidly developing diagnostic field, the precise role of brain biopsy is unknown.
Robin W. van Steenhoven   +14 more
wiley   +1 more source

First Year of Israeli Newborn Screening for Severe Combined Immunodeficiency—Clinical Achievements and Insights

open access: yesFrontiers in Immunology, 2017
Severe combined immunodeficiency (SCID), the most severe form of T cell immunodeficiency, is detectable through quantification of T cell receptor excision circles (TRECs) in dried blood spots obtained at birth.
Erez Rechavi   +27 more
doaj   +1 more source

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

open access: yesFrontiers in Veterinary Science, 2022
Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems.
Renan B. Sper   +24 more
doaj   +1 more source

Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting

open access: yesAdvanced Functional Materials, EarlyView.
Integrating selective RNA shortcut, targeted gene isolation, and micro‐arrayed nanoimaging, the NanoPick‐array platform excels in detecting severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at just 60 copies µL−1 and accurately differentiating variants at the single‐nucleotide level. It ensures 100% accuracy for samples with cycle threshold (
Zixun Wang   +9 more
wiley   +1 more source

Newborn Screening for Severe Combined Immunodeficiency in Israel

open access: yesInternational Journal of Neonatal Screening, 2017
Newborn screening (NBS) programs for severe combined immunodeficiency (SCID), the most severe type of primary immunodeficiency, are being implemented in more and more countries with every passing year.
Erez Rechavi   +5 more
doaj   +1 more source

Omenn syndrome: the drama of a family, congenital ichthyosis is not always mundane!

open access: yesJournal of Ideas in Health, 2023
Background: The case we are reporting is about one of the rare manifestations of severe combined immunodeficiency, Omenn syndrome (OS). Case presentation: A 43-days-old female presented with thick diffuse erythrodermic scaly ichthyosiform lesions on ...
Massilia Bouhmidi   +6 more
doaj   +1 more source

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

open access: yesAdvanced Healthcare Materials, EarlyView.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli   +3 more
wiley   +1 more source

Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

open access: yesCancer, Volume 129, Issue 3, Page 426-440, 1 February 2023., 2023
Abstract Background Survivors of Hodgkin lymphoma (HL) are at risk of developing non‐Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown.
Isabelle M. Dudley   +38 more
wiley   +1 more source

Comparison of Genetically Engineered Immunodeficient Animal Models for Nonclinical Testing of Stem Cell Therapies

open access: yesPharmaceutics, 2021
For the recovery or replacement of dysfunctional cells and tissue—the goal of stem cell research—successful engraftment of transplanted cells and tissues are essential events.
Yoon-Young Kim   +5 more
doaj   +1 more source

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