Results 81 to 90 of about 287,217 (298)

The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions

Journal of Allergy and Clinical Immunology, 2022
C. Dvorak, Elie Haddad, J. Heimall, E. Dunn, R. Buckley, D. Kohn, M. Cowan, S. Pai, Linda M. Griffith, G. Cuvelier, H. Eissa, Ami J. Shah, R. O'reilly, M. Pulsipher, N. Wright, R. Abraham, L. Satter, L. Notarangelo, J. Puck   +18 more
semanticscholar   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Follow-up Study of a Child with Severe Combined Immune Deficiency

Acta Biomedica Scientifica, 2019
We present the results of 7-year follow-up of a patient with primary immunodeficiency, such as severe combined immune deficiency, X-linked variant. The child has been ill from 11 month of age.
T. B. Pavlova, V. M. Shinkareva
doaj   +1 more source

The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions

Journal of Allergy and Clinical Immunology, 2022
C. Dvorak, Elie Haddad, J. Heimall, E. Dunn, M. Cowan, S. Pai, N. Kapoor, L. Satter, R. Buckley, R. O'reilly, S. Chandra, J. Bednarski, O. Williams, Ahmad Rayes, T. Moore, C. Ebens, B. D. Dávila Saldaña, A. Petrovič, Deepak Chellapandian, G. Cuvelier, Mark T. Vander Lugt, Emi H. Caywood, S. Chandrakasan, H. Eissa, Fred D Goldman, E. Shereck, V. Aquino, K. Desantes, Lisa M. Madden, H. Miller, Lolie C. Yu, Larisa Broglie, A. Gillio, Ami J. Shah, A. Knutsen, Jeffrey P. Andolina, A. Joshi, P. Szabolcs, Malika Kapadia, Caridad Martinez, Roberta E Parrot, K. Sullivan, S. Prockop, R. Abraham, M. Thakar, J. Leiding, D. Kohn, M. Pulsipher, Linda M. Griffith, L. Notarangelo, J. Puck   +50 more
semanticscholar   +1 more source

Newborn Screening for Severe Combined Immunodeficiency in the US: Current Status and Approach to Management

International Journal of Neonatal Screening, 2017
In the US, the assay of T cell receptor excision circles (TRECs) in newborn dried blood spot specimens to detect severe combined immunodeficiency (SCID) was first piloted in 2008 in the state of Wisconsin.
M. Dorsey, J. Puck
semanticscholar   +1 more source

Severe Combined Immunodeficiency due to NHEJ1 Deficiency [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

Approach to the child with recurrent infections

Journal of Family and Community Medicine, 2009
Children with a history of recurrent, severe, or unusual infections present a diagnostic challenge. It is important to maintain a high index of suspicion for the diagnosis of immunodeficiency, for early diagnosis and treatment can improve outcome ...
Suzan A AlKhater
doaj  

Newborn screening for severe combined immunodeficiency: a primer for clinicians

Canadian Medical Association Journal, 2017
KEY POINTS Severe combined immunodeficiency is caused by genetic defects that profoundly impair development of the immune system.[1][1],[2][2] The condition is fatal early in life if affected infants do not receive therapy to restore immune function in ...
C. Biggs, E. Haddad, T. Issekutz, C. Roifman, S. Turvey   +4 more
semanticscholar   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source