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Long term outcomes of severe combined immunodeficiency: therapy implications [PDF]
Expert Review of Clinical Immunology, 2017 IntroductionNewborn screening has led to a better understanding of the prevalence of Severe Combined Immunodeficiency (SCID) overall and in terms of specific genotypes.
Jennfier Heimall, Morton Cowan
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Autoimmunity in severe combined immunodeficiency (SCID)
Blood, 2002Arkwright et al[1][1] are to be complimented for their review on autoimmunity in human primary immunodeficiency diseases. While they emphasized the role of opportunistic infections, which are common in primary immunodeficiency (PID) states in the development of autoimmune disorders, we would like ...
Ronit Elhasid +2 more
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Human Taenia in Severe Combined Immunodeficiency (SCID) Mice
Parasitology Today, 1999A rodent model for the development of the larval stages of human taeniid tapeworms would help advance immunodiagnosis in human and domestic animals and vaccine development for cysticercosis cellulosae or bovis in domestic animals. Here, Akira Ito and Mamoru Ito review recent results demonstrating the potential of the severe combined immunodeficiency ...
A, Ito, M, Ito
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Newborn screening for severe combined immunodeficiency (SCID): a review
Frontiers in Bioscience, 2005Because prompt intervention may prevent complications, early diagnosis is important in many inherited metabolic diseases. Early diagnosis of Severe Combined Immunodeficiency (SCID) is critical - because chances for successful treatment are highest for infants who have not yet experienced severe opportunistic infections.
Hai, Huang, Kenneth G, Manton
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The Case for Mandatory Newborn Screening for Severe Combined Immunodeficiency (SCID)
Journal of Clinical Immunology, 2014Severe combined immunodeficiency (SCID) is the most severe form of inherited primary immunodeficiency and is a paediatric emergency. Delay in recognising and detecting SCID can have fatal consequences and also reduces the chances of a successful haematopoietic stem cell transplant (HSCT).
H B, Gaspar +4 more
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Strategies for Retrovirus-Based Correction of Severe, Combined Immunodeficiency (SCID)
2012Severe combined immunodeficiencies (SCIDs) appear as optimal disease targets to challenge potential efficacy of gene therapy. Ex vivo, retrovirally mediated gene transfer into hematopoietic progenitor cells has been shown to provide sustained correction of two forms of SCID, that is, SCID-X1 and adenosine deaminase deficiencies.
Fischer A +2 more
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Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID)
1980The effects of bone marrow or fetal lymphoid organ transplants in 15 patients with severe combined immunodeficiency disease are reported. The benefits and dangers inherent to the various transplantation strategies are discussed. Our studies indicate that, even in the group of patients with B cells, bone marrow transplantation may be the best procedure ...
C, Griscelli +3 more
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The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis
Cancer Letters, 1995In the present study, we engrafted normal colonic epithelial and histologically diagnosed colonic adenomas from a familial adenomatous polyposis (FAP) patient into severe combined immunodeficient (SCID) mice and subsequently examined them histologically and molecular biologically. Successful engraftment and metastasis was observed. The facts that human
T, Ito +9 more
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[Newborn screening for severe combined immunodeficiencies (SCID) in Germany].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2023Patients with a severe combined immunodeficiency (SCID) harbor genetic mutations disrupting T cell immunity and hence suffer severe, life-threatening infections or manifestations of immune dysregulation within the first months of their life. The only cure is to correct their immune system, usually by means of hematopoietic stem cell transplantation ...
Sujal, Ghosh +6 more
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Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice
Histochemistry and Cell Biology, 2008To assess the in vivo influence of the systemic immune system upon microglia, six defined brain regions of adult SCID mice (n = 10) lacking functional T- and B-lymphocytes have been analyzed by NDPase histochemistry, morphometry and immunohistochemistry.
Dietrich E, Lorke +2 more
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