Results 61 to 70 of about 4,527,439 (244)

Erupção a fármaco com eosinofilia e sintomas sistémicos (síndrome DRESS).

Acta Médica Portuguesa, 2008
Adverse cutaneous reactions to drugs are frequent, affecting from 2% to 3% of all hospitalized patients. But only about 2% of these cutaneous reactions are severe and seldom are fatal.
Inês Lobo, Márcia Ferreira, Glória Velho, Madalena Sanches, Manuela Selores   +4 more
doaj   +1 more source

Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool. [PDF]

, 2011
To develop and test a new adverse drug reaction (ADR) causality assessment tool (CAT)
Smyth, RL, Williamson, PR, Gallagher, RM, Turner, MA, Kirkham, JJ, Nunn, AJ, Bird, KA, Mason, JR, Pirmohamed, M   +8 more
core  

Adverse cutaneous drug eruptions: current understanding

, 2016
Adverse cutaneous drug reactions are recognized as being major health problems worldwide causing considerable costs for health care systems. Most adverse cutaneous drug reactions follow a benign course; however, up to 2 % of all adverse cutaneous drug ...
Schmid-Grendelmeier, P, Saulite, I, Cozzio, A, Jensen, A N, French, L E, Nägeli, M, Guenova, E; https://orcid.org/, Hoetzenecker, W, Mehra, E T   +8 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Clinical Manifestations and Prognosis Factors in Severe Cutaneous Adverse Drug Reaction (Scadr) [PDF]

Severe Cutaneous adverse drug reaction (SCADR) is a severe skin reaction due to the use of drugs that can be life-threatening. This article describes the clinical manifestations and prognosis factors that affect SCADR patients.
Oktavriana, Triasari, Lauda, Benedikta, Putri, Osdatilla Esa   +2 more
core   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

NSAIDS induced cutaneous adverse drug reaction – a case series [PDF]

, 2020
Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of cutaneous adverse reactions (CADR’s). Though there are fairly high numbers of agents which commonly cause CADR, NSAID’s holds no exception.
Sarkar, Saugata, Tripathi, Santanu Kumar, Saha, Debajyoti, Sen, Sukanta, Begum, Sabnam Ara, Gupta, Nabarun   +5 more
core   +1 more source

Phenobarbital‐Induced Toxic Epidermal Necrolysis: A Case Report

Clinical Case Reports
Adverse drug reactions (ADRs) can lead to severe consequences and increased morbidity and mortality rates. Phenobarbital is one of the most common anti‐epileptic drugs that has numerous adverse drug reactions, including toxic epidermal necrolysis.
Biniyam Tedla Mamo, Solomon Getnet Meshesha, Zelalem Aysheshim Andualem, Kisi Chemeda Gutema, Abenezer Abrham Anito, Mehiret Maru Haile, Hilina Worku Jembere, Asnakech Alemu, Teshita Shute   +8 more
doaj   +1 more source

Severe Cutaneous Adverse Drug Reactions in Pediatric Patients: A Multicenter Study

, 2017
BACKGROUND: The severe cutaneous adverse drug reactions (SCARs) are rare but could be life-threatening. These include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), and acute ...
Betul Buyuktiryaki, Belgin Emine Usta Guc, Mustafa Erkocoğlu, Hikmet Tekin Nacaroglu, Guvenir, Hakan, Misirlioglu, Emine Dibek, Erkocoglu, Mustafa, Buyuktiryaki, Betul, Ersoy Civelek, Orhan, Fazil, Can Naci Kocabas, Toyran, Muge, Emine Dibek Misirlioglu, Mehtap Haktanir Abul, Nacaroglu, Hikmet Tekin, Kocabas, Can Naci, Guc, Belgin Emine Usta, Semiha Bahceci, Hakan Guvenir, Fazil Orhan, Civelek, Ersoy, Abul, Mehtap Haktanir, Can, Demet, Muge Toyran, Bahceci, Semiha, Ginis, Tayfur, Demet Can, Tayfur Ginis   +27 more
core   +1 more source