Results 71 to 80 of about 4,527,439 (244)

Assessment of the causality of drug induced cutaneous manifestations

MRIMS Journal of Health Sciences, 2015
Background: A wide spectrum of cutaneous manifestations ranging from Maculopapular rash to severe Toxic Epidermal Necrolysis (TEN) can be produced by different classes of drugs. Some severe ACDRs may result in serious morbidity and even death. Objective:
Janardan Upadhyay, B Raghvendra Rao
doaj   +1 more source

Severe cutaneous adverse drug reactions: A clinicoepidemiological study

, 2015
Background: Drug eruptions range from transient erythema to the life threatening severe cutaneous adverse reactions (SCAR) that encompass Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP ...
Sarita Sasidharanpillai, Uma Rajan, Manikoth P Binitha, Anza Khader, Deepthi N Sureshan, Najeeba Riyaz   +5 more
core   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Adverse cutaneous reactions to soft tissue fillers - a review of the histological features

, 2008
The enhanced use of exogenous substances for cosmetic and reconstructive procedures is paralleled by an increase in reports of cutaneous adverse reactions to several of these agents.
Bhawan, Jag, Ophelia Entsir Dadzie, Therese El Helou, Tania Philips, Meera Mahalingam, Parada, Meire [UNIFESP], Philips, Tania, El Helou, Therese, Meire Parada, Jag Bhawan, Dadzie, Ophelia Entsir, Mahalingam, Meera   +11 more
core   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

A Severe Case of Cutaneous Adverse Drug Reaction Secondary to a Novice Drug: Idelalisib

Journal of Investigative Medicine High Impact Case Reports, 2017
Phosphatidylinositol 3-kinase δ (PIK3δ) is a tyrosine kinase essential for B cell survival, making it an important target in the treatment of chronic lymphocytic leukemia.
Joseph Gabriel Gabriel MD, Aaysha Kapila MD, Alexei Gonzalez-Estrada MD   +2 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction [PDF]

, 2012
Background: There is little research on parents' experiences of suspected adverse drug reactions in their children and hence little evidence to guide clinicians when communicating with families about problems associated with medicines.
Smyth, RL, Young, B., Hesselgreaves, H, Munir Pirmohamed (40546), Janine Arnott (128747), Turner, M.A., Anthony J Nunn, Rosalind L. Smyth (80205), Mark A. Turner (114089), Hesselgreaves Hannah, Nunn, Anthony J., Nunn Anthony J., Nunn, Anthony J, Turner, Mark A, Matthew Peak (114087), Hesselgreaves, H., Pirmohamed, Munir, Nunn, AJ, Pirmohamed, M, Peak, M, Munir Pirmohamed, Smyth Rosalind L., Janine Arnott, Arnott Janine, Pirmohamed Munir, Nunn, A.J., Hannah Hesselgreaves (128748), Peak, M., Bridget Young (128749), Hannah Hesselgreaves, Bridget Young, Anthony J. Nunn (114088), Young, Bridget, Matthew Peak, Arnott, J, Turner Mark A., Turner, MA, Young, B, Rosalind L Smyth, Pirmohamed, M., Smyth, Rosalind L., Hesselgreaves, Hannah, Mark A Turner, Smyth, Rosalind L, Arnott, Janine, Young Bridget, Peak Matthew, Arnott, J., Smyth, R.L., Peak, Matthew, Turner, Mark A.   +50 more
core   +1 more source

Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors

British Journal of Clinical Pharmacology, EarlyView.
Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem, Mohannad N. AbuHaweeleh, Humam Emad Rajha, Mhd Osama Rahhal, Ahmad Hamdan, Lina Naseralallah   +5 more
wiley   +1 more source