Results 121 to 130 of about 1,676,317 (259)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Impact of prior dengue infection on severity and outcomes: meta-analysis of placebo-controlled trials

Revista Panamericana de Salud Pública
Objective. This study evaluated the association between serologically confirmed prior dengue infection and the subsequent risk of virologically confirmed dengue, severe dengue, dengue hospitalization, dengue-related death and all-cause mortality. Methods.
Alejandro Macchia, Silvana Figar, Cristián Biscayart, Fernán González Bernaldo de Quirós   +3 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Current advances in 2025: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee

Transfusion, EarlyView.
Nabiha H. Saifee, Jennifer Andrews, Mary Berg, Stella T. Chou, Mischa Covington, Elizabeth P. Crowe, Ruchika Goel, Juliana A. Guarente, Tina Ipe, Jeremy W. Jacobs, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Thane A. Kubik, Theodros Mamo, Michael F. Murphy, Kerry O'Brien, Monica B. Pagano, Anil K. Panigrahi, Jacqueline N. Poston, Scott E. Potter, Simon J. Stanworth, Moritz Stolla, Alyssa Ziman, Ryan A. Metcalf   +24 more
wiley   +1 more source

The Baboon as a Model to Study Human Health and Complex Disease

American Journal of Primatology, Volume 88, Issue 9, September 2026.
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley   +1 more source

Severe COVID-19 multisystem inflammatory syndrome versus severe dengue in children from Indonesia: a cross-sectional study

International Journal of Emergency Medicine
Introduction Severe multisystem inflammatory syndrome in children (MIS-C) and severe dengue are challenging to identify during the COVID-19 pandemic in dengue-endemic areas.
Anggraini Alam, Fina Meilyana Andriyani, Stanza Uga Peryoga   +2 more
doaj   +1 more source

Cytotoxic and Immunological Effects of Terpinolene and 1‐butyl‐3,4‐methylenedioxybenzene on Aedes aegypti Larvae

Archives of Insect Biochemistry and Physiology, Volume 123, Issue 1, September 2026.
The terpinolene + BMDB association caused severe midgut damage, increased apoptosis, reduced proliferation, and immune suppression in Ae. aegypti larvae, indicating that sublethal effects, despite higher LC50, compromise larval recovery and represent a promising strategy for integrated vector management.
Maria Clara da Nóbrega Ferreira Fernandes, Glaucilane dos Santos Cruz, Jaiurte Gomes Martins da Silva, Daniela Maria do Amaral Ferraz Navarro, Jefferson Luiz Princival, Júlio Cesar Ribeiro de Oliveira Farias de Aguiar, Clóvis José Cavalcanti Lapa‐Neto, Emmanuel Viana Pontual, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira   +9 more
wiley   +1 more source

Cytokine patterns during dengue shock syndrome [PDF]

, 2003
Objective. To investigate the patterns of tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), IL-6, interferon-c (IFN-c) and interleukin-1 receptor antagonist (IL-1Ra) during the course of dengue shock syndrome. Design. Prospective clinical study.
Suharti, C., Gorp, E. van, van der Meer, Jos W. M., Dolmans, Wil M. V., Meer, J.W.M. van der, Setiati, Tatty E., Dolmans, W.M.V., Setiati, T.E., Hack, C. Erik, Hack, C.E., Suharti, Catharina, Djokomoeljanto, R.J., van Gorp, Eric C. M., Djokomoeljanto, Robert, Gorp, E.C.M. van   +14 more
core   +1 more source

Metabolic Footprint of Drosophila S2 Cells: Findings During the Production of a Recombinant Rabies Virus Glycoprotein

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary To further increase protein expression, it is imperative to improve cellular performance, a process intrinsically linked to cell metabolism. Hence, a metabolic footprint of Drosophila S2 cells, both recombinant‐ and wild‐types, was performed to enhance the production of the recombinant rabies virus glycoprotein ...
Monize Caiado Decarli, Diogo Peres dos Santos, Daniela Matilde Correia, Amadeus Gomes de Azevedo, Claudio Alberto Torres Suazo, Ângela Maria Moraes, Renato Mancini Astray   +6 more
wiley   +1 more source

Pro- and anti-inflammatory cytokines signatures at different severity of dengue infection

Journal of Family Medicine and Primary Care
Context: Dengue disease severity and progression are determined by the host immune response, with both pro- and anti-inflammatory cytokines are key mediators.
Himani Prajapati, Vivek Kumar, Garima Mittal, Yogesh Saxena   +3 more
doaj   +1 more source