Results 61 to 70 of about 57,777 (273)

Severe Dengue with Hemophagocytosis Syndrome.

Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia, 2020
Dengue is known to cause high morbidity and mortality worldwide. In recent years, there have been increasing cases of dengue fever associated with a rare complication: hemophagocytic syndrome (HPS), which is a dangerous disorder that carries high mortality. It is associated with infections, autoimmune disorders, and malignancies.
Siti Hartini Ishak, Lili Husniati Yaacob, Azlina Ishak   +2 more
openaire   +2 more sources

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Hanta Virus Infection During Dengue Virus Infection Outbreak in Indonesia [PDF]

, 2009
Aim: to investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the WHO criteria for dengue, in which serologically were not confirmed for dengue virus infections.
Hadisaputro, Suharyo, Djokomoeljanto, Robert J., Dolmans, Wil M.V., Groen, Jan, Osterhaus , Ab D.M.E, Suharti, Catharina, Meer, Jos W.M. van der, Gorp, Eric C.M. van   +7 more
core  

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Variables epidemiológicas en pacientes con sospecha de dengue

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Fundamento: no se avizora la desaparición a corto plazo de los factores que favorecen la diseminación del Aedes aegypti y el incremento en la circulación del virus del dengue. A finales del año 2013 fue abierto un hospital de campaña en Las Tunas, debido
Sarah María Regueira Betancourt, Manuel de Jesús Díaz Pérez, Pabel Boris Peña Enamorado   +2 more
doaj  

Dengue severity in the elderly in Puerto Rico [PDF]

Revista Panamericana de Salud Pública, 2003
Severe dengue affects all age groups in the Americas, but little detailed information is available about this disease in the elderly. The objective of this article is to describe the disease in this age group.We reviewed suspected dengue-case investigation forms submitted with diagnostic samples as well as clinical reports from infection control nurses
Enid J, García-Rivera, José G, Rigau-Pérez   +1 more
openaire   +2 more sources

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Dengue Burden and Factors Influencing Severity in Honduras: A Descriptive and Analytical Study [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
Background: Dengue is a disease that accounts for a major morbidity and mortality in Honduras. Methods: This descriptive study used an analytical component based on the data from the National Virology Laboratory between 2016-2022.
Melba Zúniga-Gutiérrez, Marlon Meléndez, Saroni Shadai Rodríguez Montoya, Héctor Alcides Figueroa Escobar, Jorge López, Sandra Paz, Dilcia Sauceda-Acosta   +6 more
doaj   +1 more source

Development of Dengue Infection Severity Score [PDF]

ISRN Pediatrics, 2013
Objectives. To develop a simple scoring system to predict dengue infection severity based on patient characteristics and routine clinical profiles. Methods. Retrospective data of children with dengue infection from 3 general hospitals in Thailand were reviewed.
Surangrat Pongpan, Apichart Wisitwong, Chamaiporn Tawichasri, Jayanton Patumanond, Sirianong Namwongprom   +4 more
openaire   +2 more sources

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source