Results 81 to 90 of about 1,676,317 (259)

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Immunomodulation in dengue: towards deciphering dengue severity markers

Cell Communication and Signaling
Dengue is a vector-borne debilitating disease that is manifested as mild dengue fever, dengue with warning signs, and severe dengue. Dengue infection provokes a collective immune response; in particular, the innate immune response plays a key role in primary infection and adaptive immunity during secondary infection.
Manoj Kumar Dash, Sagnika Samal, Shailesh Rout, Chinmay Kumar Behera, Mahesh Chandra Sahu, Biswadeep Das   +5 more
openaire   +3 more sources

Early tocilizumab and outcomes in acute necrotizing encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Early tocilizumab and outcome in acute necrotising encephalopathy. Aim To evaluate the timing and safety of tocilizumab in acute necrotizing encephalopathy (ANE). Method This was a multicentre retrospective study evaluating outcomes (modified Rankin Scale [mRS]) in children with ANE treated with tocilizumab. A logistic regression model determined a cut‐
Velda X Han, Prithuja Poudyal, Vanessa Lee, Arushi Gahlot Saini, Shekeeb S Mohammad, Sekhar C Pillai, Gouri Rao Passi, Naveen Sankhyan, Ahmad Rithauddin Mohamed, Lokesh Lingappa, Hiroshi Sakuma, Russell C Dale, Ming Lim, Terrence Thomas, for The International ANE Study Group   +14 more
wiley   +1 more source

ACIP Dengue Vaccine Workgroup [PDF]

01-Dengue-Chen-508 ...

core   +6 more sources

Clinical spectrum and risk factors of severe dengue infection: findings from the 2023 dengue outbreak in Bangladesh

BMC Infectious Diseases
Background Since the first detection of dengue in 2000, Bangladesh has been facing an increasing number of dengue patients and related deaths every year.
Orindom Shing Pulock, Adnan Mannan, Abul Faisal Md. Nuruddin Chowdhury, Golam Tousif, Koushik Majumder, Sabrina Monsur, H. M. Hamidullah Mehedi, Emrul Kaiser, Afreen Sultana, Md Abdul Hamid Sagar, Silvia Naznin Etu, Nazmul Alam, A. H. M. Tharakul Mazid, M. A. Sattar   +13 more
doaj   +1 more source

Cardiac tamponade in a patient with severe dengue fever

Revista da Sociedade Brasileira de Medicina Tropical
A 26-year-old postpartum female presented with symptoms characteristic of dengue fever on the 16th day of puerperium. On the third day of the illness, the patient presented a clinical picture consistent with shock. Tests determined primary infection with
Ana Isabel Vieira Fernandes, Ciro Leite Mendes, Raíssa Holmes Simões, Ana Elisa Vieira Fernandes Silva, Clarissa Barros Madruga, Carlos Alexandre Antunes de Brito, Lucio Roberto Castellano, Marli Tenório Cordeiro   +7 more
doaj   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly

Journal of Microbiology, Immunology and Infection, 2018
Background/Purpose: Dengue clinically dynamically changes over time; the World Health Organization (WHO) dengue classification framework proposed 3 dengue clinical phases—febrile (days 1–3), critical (days 4–6) and recovery (days ≥7) phases.
Hong-Jie Kuo, Ing-Kit Lee, Jien-Wei Liu
doaj   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression [PDF]

, 2005
Type 1 interferons (IFN-?/?) are key mediators of innate antiviral responses but havelittle effect on established replication of dengue viruses, which are mosquito-borneflaviviruses of immense global health importance.
Jones, M, Jacobs, M, Ball, S, Hibbert, L, Foster, G, Davidson, AD, Foster, GR, Davidson, A, Gruenwald, P, Schlaak, J   +9 more
core   +1 more source