ABSTRACT The introduction of biologics, such as benralizumab (an anti‐IL‐5 receptor α humanised monoclonal antibody), has made remission a feasible goal for patients with severe eosinophilic asthma (SEA). However, there are remaining research gaps and no clear consensus on the definition of remission.
Renaud Louis+7 more
wiley +1 more source
The analysis of the effects of acupoint catgut embedding therapy on asthma control, sleep quality, as well as immune and inflammatory factors. Univariate and multivariate analysis of the effects of acupoint catgut embedding therapy. ABSTRACT Background Asthma is a chronic airway inflammatory disease that significantly affects patients' quality of life ...
Zhihong Shi+6 more
wiley +1 more source
Impact of biological therapies on laboratory outcomes and FEV1 in patients with severe eosinophilic asthma with chronic rhinosinusitis: a real-life study from Saudi Arabia. [PDF]
Abu Elhassan U+16 more
europepmc +1 more source
This study assessed the effect of switching from dual bronchodilator therapy to triple therapy in COPD. While FEV1 showed no significant change, resonant frequency improved, suggesting reduced airway inflammation. Impulse oscillometry may help detect treatment effects not captured by spirometry.
Yosuke Tanaka+11 more
wiley +1 more source
Sustained Effectiveness of Benralizumab in Naïve and Biologics-Experienced Severe Eosinophilic Asthma Patients: Results from the ANANKE Study. [PDF]
Cameli P+22 more
europepmc +1 more source
Gluten‐related skin disorders: clinical presentation, diagnostic and treatments
Summary Gluten‐related disorders (GRDs) encompass a spectrum of clinical manifestations triggered by gluten ingestion in genetically susceptible individuals. These disorders include celiac disease (CD) and non‐celiac gluten sensitivity (NCGS) and present with both intestinal and extraintestinal symptoms, including skin manifestations.
Dario Didona+2 more
wiley +1 more source
ILC2 Diversity, Location, and Function in Pulmonary Disease
ABSTRACT Type‐2 inflammation is driven by the production of canonical type‐2 cytokines IL‐4, IL‐5, and IL‐13. Type‐2 cytokines promote mucus production, innate immune cell recruitment, and smooth muscle contractility in mucosal tissues. These hallmarks of type‐2 inflammation are important contributors to the weep‐and‐sweep responses observed in the ...
Mukesh Verma+2 more
wiley +1 more source
Pathological IgE Production in Inborn Errors of Immunity and Beyond
ABSTRACT In this review, we examine different mechanisms for the generation of pathological IgE through the study of inborn errors of immunity (IEI). In particular, we focus on IEIs that are susceptible to atopic disease, such as severe eczema, eosinophilia, and/or food anaphylaxis; this group of approximately 50 genes has been coined primary atopic ...
Cindy S. Ma, Peter S. Hsu
wiley +1 more source
Dad's legacy: Epigenetic reprogramming and paternal inflammatory memory in offspring health
Abstract Over the past decade, numerous reports have highlighted intergenerational and even transgenerational epigenetic effects resulting from parental exposure to diets, toxins, and stress. In many cases, these parentally induced phenotypes do not seem to confer an obvious benefit, making it challenging to understand the evolutionary drivers behind ...
Shamila D. Alipoor+3 more
wiley +1 more source
Real-world outcomes of mepolizumab for the treatment of severe eosinophilic asthma in Canada: an observational study. [PDF]
Chapman KR+7 more
europepmc +1 more source