Results 71 to 80 of about 2,042,286 (309)

Normal and pathological dynamics of platelets in humans [PDF]

Journal of Mathematical Biology volume 75, pages 1411-1462 (2017), 2016
We develop a comprehensive mathematical model of platelet, megakaryocyte, and thrombopoietin dynamics in humans. We show that there is a single stationary solution that can undergo a Hopf bifurcation, and use this information to investigate both normal and pathological platelet production, specifically cyclic thrombocytopenia.
arxiv   +1 more source

Current status of severe fever with thrombocytopenia syndrome in China [PDF]

Virologica Sinica, 2017
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we
Yi Song, Bing Hu, Deyin Guo, Jing Cheng, Faxian Zhan, Jing Li, Qin Wang, Jianbo Zhan, Jianbo Zhan   +8 more
openaire   +3 more sources

Expert Perspectives on a Clinical Challenge: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, Accepted Article.
Systemic vasculitis describes a collection of rare diseases each caused by inflammation of blood vessel walls that can cause severe systemic complications [[3, 4]](#ref‐0003). The pattern of vascular inflammation and resultant damage is frequently variable and may be mimicked, or directly triggered, by infection or malignancy.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Severe Fever with Thrombocytopenia Syndrome Virus, Shandong Province, China

Emerging Infectious Diseases, 2012
Severe fever with thrombocytopenia syndrome, which results in severe illness and has a high case-fatality rate, is caused by a novel bunyavirus, severe fever with thrombocytopenia syndrome virus.
Li Zhao, Shenyong Zhai, Hongling Wen, Feng Cui, Yuanyuan Chi, Ling Wang, Fuzhong Xue, Qian Wang, Zhiyu Wang, Shoufeng Zhang, Yanyan Song, Jun Du, Xue-jie Yu   +12 more
doaj   +1 more source

The value of cystatin C in evaluating the severity and prognosis of patients with severe fever with thrombocytopenia syndrome

BMC Infectious Diseases, 2022
Background Severe fever with thrombocytopenia syndrome (SFTS) is a novel emerging viral infectious disease. We explore the value of cystatin C (CysC) level in the evaluation of disease severity and prognosis in patients with SFTS.
Jiao Xie, Shenghua Jie
doaj   +1 more source

A hierarchical network approach for modeling Rift Valley fever epidemics with applications in North America [PDF]

PLOS ONE 2013, 2011
Rift Valley fever is a vector-borne zoonotic disease which causes high morbidity and mortality in livestock. In the event Rift Valley fever virus is introduced to the United States or other non-endemic areas, understanding the potential patterns of spread and the areas at risk based on disease vectors and hosts will be vital for developing mitigation ...
arxiv   +1 more source

Engineering strategies to mitigate toxicities associated with CAR‐T cell therapy

BMEMat, Volume 3, Issue 1, March 2025.
This review provides a brief overview of several of the major, and potentially life‐threatening, toxicities associated with CAR T cell therapies and discusses various examples of the genetic and chemical engineering strategies employed to effectively mitigate such toxicities in preclinical models and clinical studies. Abstract Chimeric antigen receptor
Tyler Wolter, Yixin Wang, Quanyin Hu
wiley   +1 more source

Fatal Tickborne Phlebovirus Infection in Captive Cheetahs, Japan

Emerging Infectious Diseases, 2018
Two captive cheetahs from a zoo in Japan died of a severe fever with thrombocytopenia syndrome–like illness. Severe fever with thrombocytopenia syndrome virus, an endemic tickborne phlebovirus, was detected systemically with secretion of infectious ...
Keita Matsuno, Noriyuki Nonoue, Ayako Noda, Nodoka Kasajima, Keita Noguchi, Ai Takano, Hiroshi Shimoda, Yasuko Orba, Mieko Muramatsu, Yoshihiro Sakoda, Ayato Takada, Shinji Minami, Yumi Une, Shigeru Morikawa, Ken Maeda   +14 more
doaj   +1 more source

EPSTEIN-BARR-VIRUS ASSOCIATED SYNDROMES IN IMMUNOSUPPRESSED LIVER-TRANSPLANT RECIPIENTS - CLINICAL PROFILE AND RECOGNITION ON ROUTINE ALLOGRAFT BIOPSY [PDF]

, 1990
The clinical profile and histopathologic changes in needle biopsies of the liver were studied in 10 cases of acute Epstein-Barr virus infection occurring in liver transplant recipients.
DEMETRIS, AJ, MARKIN, RS, RANDHAWA, PS, STARZL, TE   +3 more
core   +1 more source

Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome

PLOS Neglected Tropical Diseases, 2017
Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identify the biomarkers reflecting endothelial ...
Xiao-Kun Li, Zhen-Dong Yang, Juan Du, Bo Xing, Ning Cui, Pan-He Zhang, Hao Li, Xiao-Ai Zhang, Qing-Bin Lu, Wei Liu   +9 more
openaire   +5 more sources