Results 101 to 110 of about 27,014 (195)

Adeno‐Associated Virus Gene Therapy for Spinal Muscular Atrophy Induces Hepatotoxicity via Cytokine and Macrophage Activation

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatotoxicity is a common and significant adverse effect associated with adeno‐associated virus (AAV) gene therapy; however, the underlying mechanisms remain unknown. In this study, we demonstrated innate immune activation in two patients with spinal muscular atrophy shortly after receiving AAV9 gene therapy with onasemnogene abeparvovec ...
Aiko Sakai, Masaya Sugiyama, Masafumi Onodera, Fujiko Fukushima, Mai Tanaka, Toru Uchiyama, Masashi Mizokami, Ryo Sumazaki   +7 more
wiley   +1 more source

Unusual case of severe fever with thrombocytopenia syndrome showing clinical manifestations in a companion dog

Veterinary Medicine and Science, 2020
Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging zoonotic virus in East Asia. However, SFTS virus (SFTSV) has not been reported to cause clinical infection in companion dogs to date. We report the case of a 4‐year‐old companion dog
So‐Jeong Nam, Ye‐In Oh, Hyun‐Jung Kim, Doo‐Sung Cheon, Sung‐Jun Noh, Yeon‐Jung Hong   +5 more
doaj   +1 more source

In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus [PDF]

, 2016
Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus.
Kye-Hyung Kim, Oh, Myoung-don, Kim, Kye-Hyung, Myung Jin Lee, Choi, Su Jin, Wan Beom Park, Su Jin Choi, Pyoeng Gyun Choe, Jongyoun Yi, Yi, Jongyoun, Nam Joong Kim, Park, Wan Beom, Kim, Nam Joong, Lee, Myung Jin, Myoung-don Oh, Choe, Pyoeng Gyun   +15 more
core   +1 more source

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice [PDF]

, 2019
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR-/- mice challenged with the ...
Brett L. Hurst, Hickerson, Brady T., Steiner, Thomas, Takashi Komeno, Wülfroth, Petra, Van Wettere, Arnaud J., Hurst, Brett L., Thomas Steiner, Kurz, Jacqueline P., Gowen, Brian B., Arnaud J. Van Wettere, Brady T. Hickerson, Ashley Dagley, Dagley, Ashley, Brian B. Gowen, Furuta, Yousuke, Westover, Jonna B., Jacqueline P. Kurz, Komeno, Takashi, Petra Wülfroth, Jonna B. Westover, Yousuke Furuta   +21 more
core   +2 more sources

Diagnostics of Severe Fever with Thrombocytopenia Syndrome – Disease, Caused by Novel Phlebovirus [PDF]

, 2016
In 2009, a novel virus, named severe fever with thrombocytopenia syndrome (SFTS) virus, was isolated from a patient in China. The illness caused by this novel virus is characterized by a sudden onset of fever and respiratory or gastrointestinal disorders,
T. E. Sizikova, S. V. Borisevich, V. N. Lebedev, N. V. Boyarskaya   +3 more
core   +2 more sources

Novel Bunyavirus in Domestic and Captive Farmed Animals, Minnesota, USA

Emerging Infectious Diseases, 2013
We tested blood samples from domestic and captive farmed animals in Minnesota, USA, to determine exposure to severe fever with thrombocytopenia syndrome virus and Heartland-like virus.
Zheng Xing, Jeremy Schefers, Marc Schwabenlander, Yongjun Jiao, Mifang Liang, Xian Qi, Chuan Li, Sagar Goyal, Carol J. Cardona, Xiaodong Wu, Zerui Zhang, Dexin Li, James Collins, Michael P. Murtaugh   +13 more
doaj   +1 more source

SFTS exerts an underrecognized disease burden and socioeconomic effect in East Asia

Biosafety and Health
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus that poses a growing public health concern, especially in East Asia.
Wen Zheng, Fang Zhong, Weixue Wang, Hengcong Liu, Yu Peng, Michael J. Carr, Zhihang Peng, Weifeng Shi   +7 more
doaj   +1 more source

Replication capacity and adaptability of a severe fever with thrombocytopenia syndrome virus at different temperatures. [PDF]

, 2017
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease caused by the SFTS virus (SFTSV). Although fever and thrombocytopenia are the typical manifestations of SFTS, a specific SFTS case with no fever was observed in Zhejiang, China. In
Cixiu Li, Junfen Lin, Changping Xu, Yiyu Lu, Yan Feng, Yanjun Zhang, Zhongfa Wang, Jianmin Jiang   +7 more
core   +1 more source

Transmission of Severe Fever with Thrombocytopenia Syndrome (SFTS) to humans: A systematic review of individual participant data and meta-analysis

Journal of Infection and Public Health
Severe Fever with Thrombocytopenia Syndrome (SFTS) is a life-threatening emerging infectious disease caused by the SFTS virus. The aim of this systematic review and meta-analysis was to gain new insights into the routes of transmission to humans and ...
Darae Woo, Ian C. Michelow, Yongyeon Choi, Hyelan Lee, Sangshin Park   +4 more
doaj   +1 more source

Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors [PDF]

, 2017
Aims Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan. The causative virus severe fever with thrombocytopenia syndrome virus (SFTSV) is
Masaaki Toyama, Norikazu Sakakibara, Mika Okamoto, Naomichi Arima, Masanori Baba, Masayuki Saijo   +5 more
core   +1 more source