Results 81 to 90 of about 27,014 (195)

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, EarlyView.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus [PDF]

Journal of Virology, 2016
ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever with a high case fatality rate caused by SFTS virus (SFTSV). Effective vaccines and specific therapies for SFTS are urgently sought, and investigation into virus-host cell interactions is expected to contribute to the development of antiviral ...
Hideki, Tani, Masayuki, Shimojima, Shuetsu, Fukushi, Tomoki, Yoshikawa, Aiko, Fukuma, Satoshi, Taniguchi, Shigeru, Morikawa, Masayuki, Saijo   +7 more
openaire   +2 more sources

Mild Clinical Course of Severe Fever with Thrombocytopenia Syndrome Virus Infection in an Elderly Japanese Patient [PDF]

, 2014
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious and hemorrhagic disease recently described in China and western Japan. A 71-year-old healthy Japanese woman noticed a tick biting her after harvesting in an orchard and removed ...
Hiromichi Nakamoto, Masayuki Shimojima, Tokuzo Fujimoto, Chiaki Nakamoto, Shinobu Tamura, Yoshio Nakano, Yuko Ohagi, Masayuki Saijo   +7 more
core   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Cytokine and Chemokine Levels in Patients with Severe Fever with Thrombocytopenia Syndrome Virus

PLoS ONE, 2012
Severe fever with thrombocytopenia syndrome virus (SFTSV), which can cause hemorrhagic fever-like illness, is a newly discovered bunyavirus in China. The pathogenesis of SFTSV infection is poorly understood. However, it has been suggested that immune mechanisms, including cytokines and chemokines, play an important role in disease pathogenesis.
Baocheng Deng, Shujun Zhang, Yingzhi Geng, Yuzhong Zhang, Yuncheng Wang, Wenqing Yao, Ying Wen, Wei Cui, Ying Zhou, Qiuhong Gu, Wen Wang, Yu Wang, Zhen Shao, Yanli Wang, Chengbo Li, Donglei Wang, Yitong Zhao, Pei Liu   +17 more
openaire   +4 more sources

Beyond the Kidney and Lung: Cutaneous and Mucosal Clues to Human Hantavirus Disease

International Journal of Dermatology, EarlyView.
Rodent exposure and aerosolized excreta can lead to hantavirus infection with systemic endothelial injury and capillary leak, resulting in thrombocytopenia and syndromes such as HPS/HCPS and HFRS/NE. Early dermatologic and mucosal findings, including flushing, conjunctival injection, petechiae/purpura, and mucosal bleeding, may provide important clues ...
Giuseppe Gallo, Pietro Quaglino, Simone Ribero   +2 more
wiley   +1 more source

Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan [PDF]

, 2016
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease in East Asia. It is thought that the SFTS virus (SFTSV) circulates between ticks and animals in nature and that the virus is transmitted to humans by tick bites. SFTS is endemic to
Shimada, Satoshi, Daisuke Hayasaka, Satoshi Shimada, Guillermo Posadas-Herrera, Fuxun, Yu, Morita, Kouichi, Agoh, Masanobu, Yoshikawa, Akira, Posadas-Herrera, Guillermo, Akira Yoshikawa, Kouichi Morita, Yu Fuxun, Tun, Mya Myat Ngwe, Masanobu Agoh, Mya Myat Ngwe Tun, Hayasaka, Daisuke   +15 more
core   +2 more sources

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

View Point on Severe Fever with Thrombocytopenia Syndrome [PDF]

, 2013
Severe fever with thrombocytopenia syndrome (SFTS), a new disease of zoonotic natural foci has been increasing in recent years. In this review, the disease of human granulocytic anaplasmosis infection due to tickborne and new Bunia virus infection, have ...
Chuan-Song Hu, Ji-bin Ye, Tai-Sheng Li, Li Fang   +3 more
core   +1 more source

Severe Fever with Thrombocytopenia Syndrome Virus Infection of Cell Cultures

Bio-Protocol, 2014
Severe fever with thrombocytopenia syndrome virus (SFTSV) can infect multiple cells, such as Vero, RD, BHK21, HUVEC and 293T. Vero cells are highly susceptible, so they were used to isolate virus from sera of patients, as well as for producing virus in ...
Yinyan Sun, Wenhui Li
doaj   +1 more source