Results 71 to 80 of about 65,665,756 (179)

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

Challenges of Dengue in Hematological Disease Patients: Descriptive Analysis From the DANGO Registry During the 2023–2024 Outbreak in Argentina

Transplant Infectious Disease, EarlyView.
During the 2023–2024 Argentine dengue outbreak, 33 patients with hematological disease showed high complication rates, frequent hospitalization (64%), severe thrombocytopenia (90%), and 6% dengue‐attributable mortality. Transfusion‐associated cases were documented.
Gustavo Adolfo Méndez, Carla Niveyro, Pedro Andrés Villalba Apestegui, Victoria Isabel Martin, Lucila María Compañy Kec, María Cynthia Tomasino, Mariana del Carmen del Marull, Haydee Ingrid Bernard, Claudia Patricia Lorena Fernández, Flavia Marcela Pelech, Maria Fernanda Tosin, María Fernanda González‐Hobecker, Karen Beatrice Duranona, Angela Daiana Jara, Justus Cornely, Oliver A. Cornely, Jon Salmanton‐García   +16 more
wiley   +1 more source

Risk Factors for Mortality in Dengue Shock Syndrome (DSS) [PDF]

, 2009
Background: Dengue shock syndrome (DSS) is the most severe form of dengue hemorrhagic fever (DHF) and has a high mortality. There are two major pathological changes in DHF determining the severity of disease, plasma leakage and bleeding.
Djokomoeljanto, Robert J, Gorp, Eric CM Van, Dolmans, Wil MV, Trastotenojo, Moeljono S, Meer, Jos WM van der, Setiati , Tatty E, Suharti, Catharina   +6 more
core   +1 more source

Human Herpesvirus 8 Causes a Wide Spectrum of Disease in Liver Transplant Recipients and May be Donor Derived: Case Series and Systematic Review of an Emerging Challenge

Transplant Infectious Disease, EarlyView.
Among 135 cases of post‐liver transplant HHV8 disease (4 from NSW), presentations varied, and mortality was high (44%). Donor screening was rare, and donor‐derived infection was suspected in 33%. Survival improved with mTORi, reduced immunosuppression, chemotherapy, and, for non‐KS disease, donor screening. ABSTRACT Background Human herpesvirus 8 (HHV8)
Karen M. J. Waller, Sudarshan Arvind, Simone I. Strasser, Ken Liu, Geoff W. McCaughan, David G. Bowen, Madeleine Gill, Rebecca Davis, William Rawlinson, Sacha Stelzer‐Braid, Geoff Watson, Vinay Vanguru, Tina Marinelli   +12 more
wiley   +1 more source

Severe Fever with Thrombocytopenia Syndrome Virus Infection of Cell Cultures

Bio-Protocol, 2014
Severe fever with thrombocytopenia syndrome virus (SFTSV) can infect multiple cells, such as Vero, RD, BHK21, HUVEC and 293T. Vero cells are highly susceptible, so they were used to isolate virus from sera of patients, as well as for producing virus in ...
Yinyan Sun, Wenhui Li
doaj   +1 more source

Toxicity of Cytarabine Intravenous Constant Rate Infusion in Cats With Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Cytarabine intravenous constant rate infusion (IV CRI) toxicity in cats with lymphoma has not been well documented. We aimed to assess toxicities following cytarabine IV CRI as a single‐agent or within a multiagent protocol in cats with lymphoma. Medical records of cats with lymphoma treated with cytarabine IV CRI, with documented dose, route,
Rachel Hanford, Katherine A. Skorupski, Robert B. Rebhun, Rachel V. Brady, Sami Al‐Nadaf, Amandine T. Lejeune   +5 more
wiley   +1 more source

Severe fever with thrombocytopenia syndrome virus infection or mixed infection with scrub typhus in South Korea in 2000-2003

, 2019
Severe fever with thrombocytopenia syndrome is a tick-borne viral disease, with a high mortality rate that was first reported in China in 2009. Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi, a bacterium transmitted to humans ...
Ro, Hyo-Jin, Jeon, Kyeongseok, Kim, Hong-Il, Kim, Yuri, Kim, Chaewon, 조남혁, Nguyen Thi Hai Yen, Park, Dahee, Jeong, Seonyoung, Lee, Keun Hwa, Kang, Jun-Gu, Choi, Myung-Sik, Cho, Nam-Hyuk, Choi, Hooncheol   +13 more
core   +1 more source

SFTSV infection drives platelet-associated fibrinogen accumulation and platelet-mediated coagulopathy

Research and Practice in Thrombosis and Haemostasis
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever characterized by high mortality, thrombocytopenia, and coagulation abnormalities.
Chenhui Lin, Ling Xu, Chaoxiong Yue, Yaohui Fang, Jingyuan Zhang, Jie Fu, Hanxin Li, Xiaoyu Hu, Jianlun Xu, Haixia Yang, Chunxia Guo, Yan Ma, Fei Deng, Xin Zheng, Fengwu Qiu, Shu Shen   +15 more
doaj   +1 more source

Causes and Outcome of Systemic Inflammatory Response Syndrome in Dogs: An Observational Study of 172 Cases

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To evaluate the clinical characteristics, underlying diseases, organ dysfunctions, and survival of dogs with systemic inflammatory response syndrome (SIRS) or sepsis. Design Prospective observational study from January to December, 2023. Setting Single‐center, veterinary university teaching hospital.
Myriam A. Knopf, Christiane Weingart, Roswitha Merle, Teresa Sandbrink, Antina Lübke‐Becker, Marcus Fulde, Caroline Robé, Marianne Skrodzki, Uwe Rösler, Stefan Schwarz, Barbara Kohn   +10 more
wiley   +1 more source