Results 61 to 70 of about 65,665,756 (179)

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, EarlyView.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice

, 2023
We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites.
Hye Won Kwak, Kyeongseok Jeon, Nam-Hyuk Cho, Jae-Yong Kim, Do-Hyung Kim, Yoo-Jin Bang, Eun-Jin Choi, Jae-Hwan Nam, Soo-Yeon Lee, Hyeong-Jun Park, Sang-In Park   +10 more
core   +1 more source

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

British Journal of Haematology, EarlyView.
Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters ...
Matthias Bleeke, Arne Simon, Beate Winkler, Sabine Heine, Anna Eichinger, Ulrich von Both, Meinolf Siepermann, Sonya El Amouri, Arndt Borkhardt, Yvonne Pritschow, Wolfgang Novak, Michael Dworzak, Sarah Goretzki, Clara Held, Karin Beutel, Franziska Gams, Henriette Rudolph, Leila Koscher, Piet E. Beusker, Eckard Hamelmann, Stefan Weichert, Svenja Häuser, Maximilian Mauritz, Malik Aydin, Verena Wiegering, Regine Grosse, Rainer Misgeld, Martina Stiefel, Nicole Töpfner, Uta Falke, Lara Imhof, Laura Tagliaferri, Daniel Ebrahimi‐Fakhari, Andreas Groll, Marion Appel, Nora Naumann‐Bartsch, Michaela Nathrath, Olaf Beck, Solvej Heidtmann, Philipp Tischer, Ulf Schulze‐Sturm, Urs Mücke, Holger Cario   +42 more
wiley   +1 more source

Severe Fever with Thrombocytopenia Syndrome, South Korea, 2012

, 2013
We report a retrospectively identified fatal case of severe fever with thrombocytopenia syndrome (SFTS) in South Korea from 2012. SFTS virus was isolated from the stored blood of the patient.
Jongyoun Yi, Jong-Koo Lee, Kye-Hyung Kim, Gayeon Kim, Nak-Hyun Kim, Kang Il Jun, Nam-Joong Kim, Myoung-don Oh, Su Jin Choi, Pyoeng Gyun Choe   +9 more
core   +1 more source

Leukemoid Reaction in Complicated Haemorrhagic Fever with Renal Syndrome [PDF]

Journal of Clinical and Diagnostic Research, 2017
Hantaan Virus (HTNV) infections are mostly associated with fever, haemorrhagic and renal manifestations, known as Haemorrhagic Fever with Renal Syndrome (HFRS). We herein describe three cases with acute HTNV infection, confirming that HTNV infection may
Xiaopeng Yang, Sanming Chai, Xining Xu, Ling Hui, Meiliang Wang   +4 more
doaj   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Healthy Persons, China, 2013 [PDF]

, 2014
In June 2013, a subclinical infection with severe fever with thrombocytopenia syndrome virus (SFTSV) was detected in Zhejiang Province, China, prompting seroprevalence studies in 6 districts within the province.
Huakun Lv, Jie Yan, Bin Shao, Jeroen Kortekaas, Jimin Sun, Yi Sun, Zhiping Chen, Lei Zhang, Lei Zhang, Yanjun Zhang, Chengliang Chai, Jianmin Jiang   +11 more
core   +1 more source

Early tocilizumab and outcomes in acute necrotizing encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Early tocilizumab and outcome in acute necrotising encephalopathy. Aim To evaluate the timing and safety of tocilizumab in acute necrotizing encephalopathy (ANE). Method This was a multicentre retrospective study evaluating outcomes (modified Rankin Scale [mRS]) in children with ANE treated with tocilizumab. A logistic regression model determined a cut‐
Velda X Han, Prithuja Poudyal, Vanessa Lee, Arushi Gahlot Saini, Shekeeb S Mohammad, Sekhar C Pillai, Gouri Rao Passi, Naveen Sankhyan, Ahmad Rithauddin Mohamed, Lokesh Lingappa, Hiroshi Sakuma, Russell C Dale, Ming Lim, Terrence Thomas, for The International ANE Study Group   +14 more
wiley   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada [PDF]

, 2003
Although information on efficacy and adverse drug reactions is lacking, ribavirin has been used empirically for the treatment of severe acute respiratory syndrome (SARS). We report common adverse events in 110 patients with suspected or probable SARS who
Dresser, L., Linda Dresser, Larissa Matukas, Elizabeth J. Phillips, Phillips, E.J., Matukas, L., Sandra R. Knowles, Knowles, S.R.   +7 more
core   +1 more source