Results 51 to 60 of about 1,750,371 (298)

Current and future therapies to treat impaired awareness of hypoglycemia

Frontiers in Pharmacology, 2023
In order to achieve optimal glycemic control, intensive insulin regimes are needed for individuals with Type 1 Diabetes (T1D) and insulin-dependent Type 2 Diabetes (T2D).
Erica L. Macon, Micah H. Devore, Yu Kuei Lin, Megan B. Music, Mason Wooten, Colleen A. McMullen, Andrea M. Woodcox, Ashlee R. Marksbury, Zachary Beckner, Bansi V. Patel, Lily A. Schoeder, Ashley N. Iles, Simon J. Fisher   +12 more
doaj   +1 more source

Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor [PDF]

Diabetes Care, 2016
Current estimates are that 1.25 million Americans have type 1 diabetes (T1D) (1) caused by the gradual loss of nearly all pancreatic insulin-producing β-cells via a presumed T cell–mediated autoimmune process (2). Eventually, all with T1D display severely impaired endogenous insulin production (3) and are dependent upon injected insulin for survival ...
openaire   +2 more sources

Primum Non Nocere: Refocusing Our Attention on Severe Hypoglycemia Prevention [PDF]

, 2018
Severe hypoglycemia, defined as low blood glucose requiring assistance for recovery, is arguably the most dangerous complication of type 1 diabetes as it can result in permanent cognitive impairment, seizure, coma, accidents, and death.
Buse, J.B., John B. Buse, Kahkoska, A.R., Anna R. Kahkoska   +3 more
core   +1 more source

Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study

, 2022
Context: There are few studies focused on the relationship between hypoglycemia and new-onset dementia in patients with type 2 diabetes and no study regarding mortality of dementia after hypoglycemia.
차봉수, 이병완, 이용호, 강은석, Kyung-do Han, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee, Byung-Wan Lee, Seung-Hyun Ko, Eugene Han   +10 more
core   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Sepsis‐associated hypoglycemia on admission is associated with increased mortality in intensive care unit patients

Acute Medicine & Surgery, 2022
Aim Hyperglycemia is a common response to acute illness, but it is not often seen in critical conditions. The frequency and cause of hypoglycemia in septic patients have not been well elucidated.
Yumi Mitsuyama, Kentaro Shimizu, Sho Komukai, Atsushi Hirayama, Ryosuke Takegawa, Takeshi Ebihara, Tetsuhisa Kitamura, Hiroshi Ogura, Takeshi Shimazu   +8 more
doaj   +1 more source

Severe Hypoglycemia–Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia

, 2017
We previously demonstrated that insulin-mediated severe hypoglycemia induces lethal cardiac arrhythmias. However, whether chronic diabetes and insulin deficiency exacerbates, and whether recurrent antecedent hypoglycemia ameliorates, susceptibility to ...
Jennifer VanderWeele, Candace M. Reno, Justin Bayles, Simon J. Fisher, Allie Skinner, Andrew Jordan, Marina Litvin, Dorit Daphna-Iken   +7 more
core   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Repetitive hypoglycemia reduces activation of glucose-responsive neurons in C1 and C3 medullary brain regions to subsequent hypoglycemia [PDF]

, 2019
The impaired ability of the autonomic nervous system to respond to hypoglycemia is termed 'hypoglycemia-associated autonomic failure' (HAAF). This life-threatening phenomenon results from at least two recent episodes of hypoglycemia, but the pathology ...
Nedoboy, Polina E., Kakall, Zohra M., Pilowsky, Paul M., Kavurma, Mary M., Howe, Peter R., Cohen, E. Myfanwy   +5 more
core   +1 more source

Injectable Peptide‐Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery

Advanced Science, EarlyView.
An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Ranjit Shaw, Niyamat M. A. Chimthanawala, Shouvik Manna, Sadhana Sathaye, Samir K. Maji   +4 more
wiley   +1 more source