Results 51 to 60 of about 64,974 (298)

ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes

, 1997
OBJECTIVE - To evaluate the association between the use of ACE inhibitors and hospital admission for severe hypoglycemia and to explore the effects of potential confounding variables on this relationship.
Boyle, Douglas I R, McMahon, Alex, Evans, Josie, Newton, Ray W., Jung, Roland T., MacDonald, Thomas M, Morris, Andrew D, Morris, Andrew D., Mcmahon, Alexander D., Macdonald, Thomas M., Evans, Josie M.M., Pearce, Hilary, Jung, Roland T, Boyle, Douglas I.R., Newton, Ray W   +14 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Sepsis‐associated hypoglycemia on admission is associated with increased mortality in intensive care unit patients

Acute Medicine & Surgery, 2022
Aim Hyperglycemia is a common response to acute illness, but it is not often seen in critical conditions. The frequency and cause of hypoglycemia in septic patients have not been well elucidated.
Yumi Mitsuyama, Kentaro Shimizu, Sho Komukai, Atsushi Hirayama, Ryosuke Takegawa, Takeshi Ebihara, Tetsuhisa Kitamura, Hiroshi Ogura, Takeshi Shimazu   +8 more
doaj   +1 more source

Current and future therapies to treat impaired awareness of hypoglycemia

Frontiers in Pharmacology, 2023
In order to achieve optimal glycemic control, intensive insulin regimes are needed for individuals with Type 1 Diabetes (T1D) and insulin-dependent Type 2 Diabetes (T2D).
Erica L. Macon, Micah H. Devore, Yu Kuei Lin, Megan B. Music, Mason Wooten, Colleen A. McMullen, Andrea M. Woodcox, Ashlee R. Marksbury, Zachary Beckner, Bansi V. Patel, Lily A. Schoeder, Ashley N. Iles, Simon J. Fisher   +12 more
doaj   +1 more source

Severe Hypoglycemia–Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia

, 2017
We previously demonstrated that insulin-mediated severe hypoglycemia induces lethal cardiac arrhythmias. However, whether chronic diabetes and insulin deficiency exacerbates, and whether recurrent antecedent hypoglycemia ameliorates, susceptibility to ...
Jennifer VanderWeele, Candace M. Reno, Justin Bayles, Simon J. Fisher, Allie Skinner, Andrew Jordan, Marina Litvin, Dorit Daphna-Iken   +7 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Brain Regulation of Cardiac Function during Hypoglycemia

Metabolites, 2023
Hypoglycemia occurs frequently in people with type 1 and type 2 diabetes. Hypoglycemia activates the counter-regulatory response. Besides peripheral glucose sensors located in the pancreas, mouth, gastrointestinal tract, portal vein, and carotid body ...
Matthew E. Chambers, Emily H. Nuibe, Candace M. Reno-Bernstein   +2 more
doaj   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics

, 2016
Drug-drug interactions causing severe hypoglycemia due to antidiabetic drugs is a major clinical and public health problem. We assessed whether sulfonylurea use with a statin or fibrate was associated with severe hypoglycemia. We conducted cohort studies
S Cardillo, Brensinger, Colleen M., Bilker, Warren B., S Hennessy, Gagne, Joshua J., Cardillo, Serena, X Han, Leonard, Charles E., CE Leonard, Han, Xu, JH Flory, JJ Gagne, DA Flockhart, Flockhart, David A., WB Bilker, Hennessy, Sean, CM Brensinger, Flory, James H.   +17 more
core   +1 more source

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

Advanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim, Mabel Bartlett, Liyang Wang, Karl Bates, Mengdi He, Myungbo Kim, Carmel Majidi, Tzahi Cohen‐Karni   +7 more
wiley   +1 more source