Results 201 to 210 of about 235,333 (304)

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Severe malaria readmissions in Northern Uganda: a cross-sectional study. [PDF]

Malar J
Olum J, Mukunya D, Nambozo B, Nantale R, Oguttu F, Epuitai J, Lume I, Wanume B, Olupot-Olupot P, Amanya D, Kakuru A.   +10 more
europepmc   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Treatment-Seeking for Children with Suspected Severe Malaria Attending Community Health Workers and Primary Health Centres in Adamawa State, Nigeria. [PDF]

Int J Public Health
Lee TT, Omoluabi E, Ayodeji K, Yusuf O, Okon C, Brunner NC, Delvento G, Signorell A, Lambiris MJ, Kwiatkowski M, Burri C, Lengeler C, Emedo E, Cheshi F, Fashanu C, Wiwa O, Hetzel MW.   +16 more
europepmc   +1 more source

Ecologies of Risk: Malaria and Settler Landscape Transformation in 19th‐Century Ontario

American Journal of Human Biology, Volume 38, Issue 1, January 2026.
ABSTRACT Objectives This study examines how settler‐driven environmental change shaped malaria transmission and mortality in 19th‐century southern Ontario. It aimed to understand the biosocial and ecological conditions that sustained endemic malaria in a temperate, colonial context.
Amanda Cooke, Megan B. Brickley
wiley   +1 more source

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 109-118, January 2026.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

Host biomarkers and parasite biomass are associated with severe malaria in Mozambican children: a case-control study. [PDF]

Sci Rep
Varo R, Sitoe A, Madrid L, Aide P, Cuamba I, Cossa A, Jairoce C, Barrios D, Martiáñez-Vendrell X, Balanza N, Cisteró P, Ouchi D, Quintó L, Crowley VM, Gupta H, Kain KC, Mayor A, Bassat Q.   +17 more
europepmc   +1 more source

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 317-322, January 2026.
In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully, Robert J. Commons, Julie A. Simpson, David J. Price   +3 more
wiley   +1 more source

Broadly inhibitory antibodies to severe malaria virulence proteins. [PDF]

Nature
Reyes RA, Raghavan SSR, Hurlburt NK, Introini V, Bol S, Kana IH, Jensen RW, Martinez-Scholze E, Gestal-Mato M, López-Gutiérrez B, Sanz S, Bancells C, Fernández-Quintero ML, Loeffler JR, Ferguson JA, Lee WH, Martin GM, Theander TG, Lusingu JPA, Minja DTR, Ssewanyana I, Feeney ME, Greenhouse B, Ward AB, Bernabeu M, Pancera M, Turner L, Bunnik EM, Lavstsen T.   +28 more
europepmc   +1 more source

The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation

Birth Defects Research, Volume 118, Issue 1, January 2026.
ABSTRACT Background Adverse birth outcomes are important public health measures and account for a substantial public health burden. There is considerable diversity of these health endpoints, as well as in the many factors suspected or recognized to increase their risk.
Paul J. Villeneuve, Ann Aschengrau, Michelle L. Bell, Yang Cao, Mark Elwood, Guy Eslick, Shelley Harris, Leeka Kheifets, Babak Khoshnood, Robert Norman, Nelson Pace, Johan Reutfors, Jeremy M. Schraw, Jose R. Suarez‐Lopez, Gunnar Toft, R. Douglas Wilson, Christopher R. Kirman, Tyler Carneal, Sean M. Hays   +18 more
wiley   +1 more source