Results 31 to 40 of about 300,372 (264)

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

Predictors of depression among caregivers of patients with severe mental illness in Northwest Ethiopia, 2023: an explanatory sequential mixed-method study

Frontiers in Psychiatry
BackgroundSevere mental illness results in an enormous social and economic burden on affected individuals, their families, and communities, especially in developing countries, such as Ethiopia.ObjectiveThe aim of this study was to assess the level of ...
Birhanu Mengist Munie, Zelalem Birhan, Getasew Legas, Sintayehu Asnakew, Amsalu Belete, Getnet Mihretie Beyene, Kirubel Shiferaw, Anemut Tilahun Mulu, Yohannes Tesfahun Kassie, Tigabu Munye Aytenew, Assasahegn Tedla   +10 more
doaj   +1 more source

Intensive case management for severe mental illness [PDF]

Cochrane Database of Systematic Reviews, 2017
Intensive Case Management (ICM) is a community-based package of care aiming to provide long-term care for severely mentally ill people who do not require immediate admission. Intensive Case Management evolved from two original community models of care, Assertive Community Treatment (ACT) and Case Management (CM), where ICM emphasises the importance of ...
Dieterich, Marina, Irving, Claire, Bergman, Hanna, Khokhar, Mariam Ahmad, Park, Bert, Marshall, Max   +5 more
openaire   +10 more sources

Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso‐Occlusive Pain Episodes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman, Maria Yasmine, Dunia Hatabah, Noor Alzraikat, Frank Harris, Lou Ann Brown, Satheesh Chonat, Nitya Bakshi, Chris A. Rees, Carlton Dampier, Claudia R. Morris   +10 more
wiley   +1 more source

Medical student's attitude toward severe mental illness and its associated factors at the university of Gondar, Northwest Ethiopia

Heliyon
Introduction: Mental illness is mental and emotional disturbances that affect individual thinking, feeling, decision-making, mood, and daily functioning.
Mamaru Melkam, Girum Nakie, Girmaw Medfu Takelle, Likinaw Abebaw Wassie, Shegaye Shumet   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The economic impact of violence perpetration in severe mental illness: a retrospective, prevalence-based analysis in England and Wales

The Lancet Public Health, 2020
Summary: Background: Calls for increased funding for mental health services require many lines of evidence in support, including estimates of economic impact.
Morwenna Senior, MBBS, Seena Fazel, ProfMD, Apostolos Tsiachristas, PhD   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Crisis intervention for people with severe mental illnesses [PDF]

Cochrane Database of Systematic Reviews, 2012
A particularly difficult challenge for community treatment of people with serious mental illnesses is the delivery of an acceptable level of care during the acute phases of severe mental illness. Crisis-intervention models of care were developed as a possible solution.To review the effects of crisis-intervention models for anyone with serious mental ...
Murphy, Suzanne, Irving, Claire B., Adams, Clive E., Driver, Ron   +3 more
openaire   +8 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source