Results 51 to 60 of about 628,141 (359)

In vitro Selection of Probiotics for Microbiota Modulation in Normal-Weight and Severely Obese Individuals: Focus on Gas Production and Interaction With Intestinal Epithelial Cells

Frontiers in Microbiology, 2021
The intestinal microbiota plays important roles in the maintenance of health. Strategies aiming at its modulation, such as probiotics, have received a deal of attention.
Alicja Maria Nogacka, Alicja Maria Nogacka, Clara G. de los Reyes-Gavilán, Clara G. de los Reyes-Gavilán, Silvia Arboleya, Silvia Arboleya, Patricia Ruas-Madiedo, Patricia Ruas-Madiedo, Ceferino Martínez-Faedo, Ceferino Martínez-Faedo, Adolfo Suarez, Adolfo Suarez, Fang He, Gaku Harata, Akihito Endo, Nuria Salazar, Nuria Salazar, Miguel Gueimonde, Miguel Gueimonde   +18 more
doaj   +1 more source

PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders. [PDF]

, 2016
Prohormone convertase 1/3, encoded by the PCSK1 gene, is a serine endoprotease that is involved in the processing of a variety of proneuropeptides and prohormones. Humans who are homozygous or compound heterozygous for loss-of-function mutations in PCSK1

core   +2 more sources

Association of Adolescent Obesity With Risk of Severe Obesity in Adulthood [PDF]

JAMA, 2010
Although the prevalence of obesity has increased in recent years, individuals who are obese early in life have not been followed over time to determine whether they develop severe obesity in adulthood, thus limiting effective interventions to reduce severe obesity incidence and its potentially life-threatening associated conditions.
Natalie S, The, Chirayath, Suchindran, Kari E, North, Barry M, Popkin, Penny, Gordon-Larsen   +4 more
openaire   +3 more sources

Pediatric Obesity: Influence on Drug Dosing and Therapeutics [PDF]

, 2018
Obesity is an ongoing global health concern and has only recently been recognized as a chronic disease of energy homeostasis and fuel partitioning. Obesity afflicts 17% of US children and adolescents.
Ameer, Barbara, PharmD, MBA, BCPS, FCP, Weintraub, Michael, MD   +1 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Associations of adolescent obesity with hypertension, diabetes mellitus and polycystic ovaries in Arabs and Jews in Israel—a nationwide study

Frontiers in Public Health
BackgroundPrevious studies on the association of adolescent obesity with comorbid diseases in Israel were conducted predominantly in the Israeli Jewish population.GoalTo compare associations of adolescent obesity with Hypertension (HTN), Diabetes ...
Yulia Treister-Goltzman, Yulia Treister-Goltzman, Dan Nemet, Idan Menashe   +3 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Association Between Long Term Exposure to PM_2.5 and Its Components on Severe Obesity in Chinese Children and Adolescents: A National Study in China

Children
Background: The aim of this study was to explore the association between long-term exposure to particulate matter with an aerodynamic diameter
Tongjun Guo, Tianjiao Chen, Li Chen, Jieyu Liu, Xinli Song, Yi Zhang, Ruolin Wang, Jianuo Jiang, Yang Qin, Ziqi Dong, Dengcheng Zhang, Zhiying Song, Wen Yuan, Yanhui Dong, Yi Song, Jun Ma   +15 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study

Frontiers in Endocrinology, 2023
BackgroundIndividual responses to behavioural weight loss interventions can vary significantly, and a better understanding of the factors associated with successful treatment might help to target interventions for those who will benefit the most.
Francis M. Finucane, Francis M. Finucane, Francis M. Finucane, Irene Gibson, Irene Gibson, Irene Gibson, Robert Hughes, Robert Hughes, Enda Murphy, Enda Murphy, Lisa Hynes, Lisa Hynes, Aisling Harris, Aisling Harris, Brian E. McGuire, Brian E. McGuire, Mary Hynes, Mary Hynes, Chris Collins, Kevin Cradock, Suzanne Seery, Suzanne Seery, Jennifer Jones, Jennifer Jones, Jennifer Jones, Tim O’Brien, Tim O’Brien, Tim O’Brien, Martin J. O’Donnell, Martin J. O’Donnell   +29 more
doaj   +1 more source