Results 151 to 160 of about 5,229,135 (336)
Effect of organic, low-input and conventional production systems on yield and diseases in winter barley [PDF]
, 2007 The effect of organic, low-input and conventional management practices on barley yield and disease incidence was assessed in field trials over two years.
Cooper, J. M. +5 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Cross-sectional study of thyroid associated orbitopathy in a South African thyroid clinic
Journal of the Colleges of Medicine of South AfricaBackground: Thyroid-associated ophthalmopathy (TAO) is a common and debilitating manifestation of Graves’ disease (GD) associated with poor clinical outcomes including impaired quality-of-life (QoL) and socio-economic status.
Sandra De Vasconcelos +3 more
doaj +1 more source
Simultaneous epidemic development of scald and net blotch on single leaf layers of a spring barley crop [PDF]
, 2005 Background and objectives Two pathogens growing on the same leaf compete for the same resources, i.e. space and plant nutrients. This may lead to density dependent disease development.
Munk, L. +3 more
core
Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan
Journal of Allergy and Clinical Immunology, 2020 Xiaochen Li +17 more
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Zhongguo linchuang yanjiuObjective To explore the diagnostic value of optical coherence tomography angiography（OCTA）combined with fundus fluorescein angiography（FFA）in assessing the severity of diabetic retinopathy.
PENG Jinyan，CHEN Jingxia，YANG Junling，ZOU Xiulan，ZOU Yuping，PENG Lianghong
doaj +1 more source