Results 141 to 150 of about 2,937,854 (253)

Association of patient-rated severity with other outcomes in patients with painful diabetic peripheral neuropathy

, 2011
Gavin Taylor-Stokes1, James Pike1, Alesia Sadosky2, Arthi Chandran2, Thomas Toelle31Adelphi Real World, Adelphi Mill, Bollington, Macclesfield, Cheshire, UK; 2Pfizer Inc, New York, NY, USA; 3Department of Neurology, Technische Universität M& ...
Pike J, Taylor-Stokes G, Chandran A, Sadosky A, Toelle T   +4 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Influence of Fetal Hemoglobin on Hematological Parameters and Clinical Severity in Patients with Homozygous Sickle Cell Disease. [PDF]

Niger Med J
Talhar SS, Patil BU, Das DK, Ambulkar P, Waghmare JE, Jain J, Jain M, Gangane NM.   +7 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Assessment of severity scales and their use in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

, 2014
Objectives: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a physical and cognitive disabling illness, characterised predominantly by severe fatigue and a range of physiological symptoms. Variation in CFS/ME symptom severity is recognised
Staines, Don, Hardcastle, Sharni Lee, Marshall-Gradisnik, Sonya, Johnston, Samantha, Ramos, Sandra Bahia, Brenu, Ekua, Huth, Teilah Kathryn   +6 more
core  

Predictors of Severity in Hemorrhagic Fever with Renal Syndrome

International Journal of General Medicine
Lihua Huang,1,* Jun Wu,2,* Jiao Luo,1 Wei Gu1 1Department of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, People’s Republic of China; 2Department of Ophthalmology, Dali Bai Autonomous Prefecture People’s ...
Huang L, Wu J, Luo J, Gu W
doaj  

Upper-Limb Paresis Severity Is Associated With Practice Dosage During Task-Oriented Training in Subacute Stroke-An Exploratory Secondary Analysis. [PDF]

Physiother Res Int
Durairaj S, Jagadish A, Solomon JM, Levin MF.   +3 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Genetic variation in BDNF is associated with opioid use disorder severity. [PDF]

Hum Genet
Kusic DM, Salzman M, Heil J, Grant SFA, Trang KB, Zajic S, Madzo J, Brown C, Jelinek J, Calendo G, Schwarting R, Issa JJ, Scheinfeldt LB.   +12 more
europepmc   +1 more source