Results 121 to 130 of about 4,191,765 (307)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ASSOCIATION OF DIFFERENT PARAMETERS OF COMPLETE BLOOD COUNT WITH SEVERITY AND PROGNOSIS OF GUILLAIN-BARRE SYNDROME

Pakistan Armed Forces Medical Journal, 2021
Objective: Guillain-barré syndrome is the most common and most severe acute paralytic neuropathy. This study is also aimed at to know that if there is any association of parameters of complete blood count and whether these can be used as a prognostic ...
Nauman Aziz, Humera Khan, Syeda Rizwana Jafri, Fauzia Qureshi, Amna Muneeb, Ursula Akif   +5 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The systemic immune-inflammation index is significantly associated with the severity of silicosis: a 9-year retrospective study in Beijing

Frontiers in Medicine
BackgroundSilicosis shows an increasing trend with the development of new industries. However, the potential biomarkers for predicting the disease severity are lacking.
Han-Yu-Jie Kang, Si-Yu Cao, Shuai Shao, Li-Rong Liang, Zhao-Hui Tong   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Hypertriglyceridemia-Induced Acute Pancreatitis—The Milky Way Constellation—The Seven-Year Experience of a Large Tertiary Centre

Diagnostics
(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate ...
Andrei Vicențiu Edu, Mihai Radu Pahomeanu, Andreea Irina Ghiță, Dalia Ioana Constantinescu, Daniela Gabriela Grigore, Andreea Daniela Bota, Daniela Maria Luta-Dumitrașcu, Cristian George Țieranu, Lucian Negreanu   +8 more
doaj   +1 more source

Associations between sensory issues, mealtime behaviours, and food and nutrient intakes in children with Autism Spectrum Disorder : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Human Nutrition and Dietetics at Massey University, Albany, New Zealand [PDF]

, 2016
Appendix 2, BPFAS scoring sheet, redacted for copyright reasonsBackground: Sensory issues are defined as dysfunction within the integration of the seven senses within the brain.
Taylor, Nicole
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Severe Burn [PDF]

The American Journal of the Medical Sciences
n ...
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source