Results 121 to 130 of about 2,639,603 (318)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
A note on the Taylor series expansions for multivariate characteristics of classical risk processes. [PDF]
The series expansion introduced by Frey and Schmidt (1996) [Taylor Series expansion for multivariate characteristics of classical risk processes.
Usábel, Miguel A.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Characterizing individual painDETECT symptoms by average pain severity
, 2016 Alesia Sadosky,1 Vijaya Koduru,2 E Jay Bienen,3 Joseph C Cappelleri4 1Pfizer Inc, New York, NY, 2Eliassen Group, New London, CT, 3Outcomes Research Consultant, New York, NY, 4Pfizer Inc, Groton, CT, USA Background: painDETECT is a screening measure for ...
Bienen EJ +3 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The reliability of visual estimates of disease severity on cereal leaves
, 1995 Visual estimates of wheat disease severity were compared with actual severities determined using image analysis of tracings of diseased leaves. Septoria tritici, leaf senescence and Erysiphe graminis were studied. Observer estimates were widely scattered
Shaw, M. W., Parker, S. R., Royle, D. J.
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Briefing note. Severity of the December 2015 floods - preliminary analysis [PDF]
, 2016 The purpose of this briefing note is to collate some of the key points from the December 2015 Hydrological Summary, and to provide some additional context beyond the space and format constraints of the Summary.
Barker, Lucy +2 more
core
Zhongguo linchuang yanjiuObjective To explore the diagnostic value of optical coherence tomography angiography（OCTA）combined with fundus fluorescein angiography（FFA）in assessing the severity of diabetic retinopathy.
PENG Jinyan，CHEN Jingxia，YANG Junling，ZOU Xiulan，ZOU Yuping，PENG Lianghong
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source